caa a22 4500 477136885 CHVBK 20180405111721.0 cr unu---uuuuu 170330e19970101xx s 000 0 eng 10.1007/BF00127965 doi (NATIONALLICENCE)springer-10.1007/BF00127965 Fretz Heinz Cancer Research, Novartis Pharma Inc., CH-4002, Basel, Switzerland aut A practical dealkylation procedure for O,O -dimethyl-phosphotyrosyl-containing peptide-resins [Elektronische Daten] [Heinz Fretz] Summary: This paper gives a useful protocol for the demethylation of O,O-dimethyl-phosphotyrosyl peptides on solid support by means of trimethylsilyl iodide in acetonitrile. The method is demonstrated to be well suited for peptide sequences containing arginine, histidine, methionine and tryptophan. ESCOM Science Publishers B.V., 1997 O,O -Dimethylphosphotyrosine nationallicence Demethylation nationallicence Deprotection nationallicence Solid-phase synthesis nationallicence Trimethylsilyl iodide nationallicence DBU : 1,8-diazabicyclo[5.4.0]undec-7-ene nationallicence DIEA : diisopropylethylamine nationallicence DMA : dimethylacetamide nationallicence EDT : 1,2-ethanedithiol nationallicence EGF : epidermal growth factor nationallicence ESI-MS : electrospray ionisation mass spectrometry nationallicence Fmoc : 9-fluorenylmethoxycarbonyl nationallicence HPLC : high-performance liquid chromatography nationallicence MBHA : 4-methyl-benzhydrylamine nationallicence NMP : N-methyl-2-pyrrolidinone nationallicence NMR : nuclear magnetic resonance nationallicence TFA : trifluoroacetic acid nationallicence TMSBr : trimethylsilyl bromide nationallicence TMSCI : trimethylsilyl chloride nationallicence TMSI : trimethylsilyl iodide nationallicence TMSOTf : trimethylsilyl trifluoromethanesulfonate nationallicence TPTU : 2-(2-pyridon-1-yl)-1,1,3,3-tetramethyluroniumfluoroborate nationallicence tR : retention time nationallicence Letters in Peptide Science Kluwer Academic Publishers 3/6(1997-01-01), 343-348 0929-5666 3:6<343 1997 3 10989 https://doi.org/10.1007/BF00127965 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00127965 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Fretz Heinz Cancer Research, Novartis Pharma Inc., CH-4002, Basel, Switzerland aut NATIONALLICENCE 773 0- Letters in Peptide Science Kluwer Academic Publishers 3/6(1997-01-01), 343-348 0929-5666 3:6<343 1997 3 10989 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer