caa a22 4500 477137067 CHVBK 20180405111721.0 cr unu---uuuuu 170330e19970601xx s 000 0 eng 10.1007/BF02443531 doi (NATIONALLICENCE)springer-10.1007/BF02443531 Comparison of the stepwise and convergent approaches in the solid-phase synthesis of rat Tyro-atriopeptin II [Elektronische Daten] [Dimitrios Gatos, Stella Patrianakou, Olga Hatzi, Kleomenis Barlos] Summary: Tyro-Atriopeptin II was synthesized on a 2-chlorotrityl resin by both, the stepwise and the convergent approach. For both methods an Fmoc/tBu(Trt)-based protection scheme was used. The convergent methodology utilizes the sequential condensation of four protected peptide fragments. These were chosen so that after every condensation reaction, the amino-terminal region of the newly formed resin-bound peptide did not contain a β-turn. This ‘designed' convergent synthesis gave the target peptide in much higher yield and purity than the conventional stepby-step synthesis. Kluwer Academic Publishers, 1997 Atriopeptin II nationallicence 2-Chlorotrityl resin nationallicence Convergent synthesis nationallicence Solid-phase synthesis nationallicence Gatos Dimitrios Department of Chemistry, University of Patras, 26010, Patras, Greece aut Patrianakou Stella Department of Chemistry, University of Patras, 26010, Patras, Greece aut Hatzi Olga Department of Chemistry, University of Patras, 26010, Patras, Greece aut Barlos Kleomenis Department of Chemistry, University of Patras, 26010, Patras, Greece aut Letters in Peptide Science Kluwer Academic Publishers 4/3(1997-06-01), 177-184 0929-5666 4:3<177 1997 4 10989 https://doi.org/10.1007/BF02443531 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02443531 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gatos Dimitrios Department of Chemistry, University of Patras, 26010, Patras, Greece aut NATIONALLICENCE 700 1- Patrianakou Stella Department of Chemistry, University of Patras, 26010, Patras, Greece aut NATIONALLICENCE 700 1- Hatzi Olga Department of Chemistry, University of Patras, 26010, Patras, Greece aut NATIONALLICENCE 700 1- Barlos Kleomenis Department of Chemistry, University of Patras, 26010, Patras, Greece aut NATIONALLICENCE 773 0- Letters in Peptide Science Kluwer Academic Publishers 4/3(1997-06-01), 177-184 0929-5666 4:3<177 1997 4 10989 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 477137067 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer