caa a22 4500 477137105 CHVBK 20180405111721.0 cr unu---uuuuu 170330e19970601xx s 000 0 eng 10.1007/BF02443530 doi (NATIONALLICENCE)springer-10.1007/BF02443530 Fretz Heinz Oncology Research, Novartis Pharma AG, CH-4002, Basel, Switzerland aut N α-Fmoc- O, O -(dimethylphospho)-L-tyrosine fluoride: A convenient building block for the solid-phase synthesis of phosphotyrosyl peptides [Elektronische Daten] [Heinz Fretz] Summary: Fmoc-O,O-(dimethylphospho)-l-tyrosine was converted into stable Fmoc-O,O-(dimethylphospho)-L-tyrosine fluoride by means of (diethylamino) sulfur trifluoride or cyanuric fluoride. This building block was used for efficient coupling of phosphotyrosine to the adjacent sterically hindered amino acid Aib or Ac6c in, model peptide sequences as well as for the synthesis of the ‘difficult' phosphotyrosine peptide Stat91695-708. The phosphate methyl groups were cleaved on solid phase after peptide assembly by means of trimethylsilyl iodide in MeCN. Kluwer Academic Publishers, 1997 Amino acid fluoride nationallicence TPTU nationallicence Peptide-bond formation nationallicence Dialkyl amino acids nationallicence Letters in Peptide Science Kluwer Academic Publishers 4/3(1997-06-01), 171-176 0929-5666 4:3<171 1997 4 10989 https://doi.org/10.1007/BF02443530 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02443530 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Fretz Heinz Oncology Research, Novartis Pharma AG, CH-4002, Basel, Switzerland aut NATIONALLICENCE 773 0- Letters in Peptide Science Kluwer Academic Publishers 4/3(1997-06-01), 171-176 0929-5666 4:3<171 1997 4 10989 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer