caa a22 4500 477139795 CHVBK 20180405111729.0 cr unu---uuuuu 170330e19970301xx s 000 0 eng 10.1007/BF01390518 doi (NATIONALLICENCE)springer-10.1007/BF01390518 Somatostatin receptor scintigraphy in patients with pituitary adenoma [Elektronische Daten] [Andreas Rieger, Nikolai Rainov, Christiane Elfrich, Monika Klaua, Heike Meyer, Christine Lautenschläger, Winfried Burkert, Traute Mende] Presence of high-affinity somatostatin (SST) receptors in most endocrine tumor cells allowin vivo scintigraphic visualization of these neoplasms after intravenous administration of a radionuclide-labeled somatostatin analog.n1In-octreotide is at present the most often used substance for imaging of the SST receptor expressionin vivo. The aim of this study is to investigate the correlation between presence ofin vivo scintigraphically detectable SST receptors in pituitary tumors and clinical parameters such as patients' age, tumor size, hormonal hypersecretion, and response to octreotide therapy. Forty-two consecutive patients were enrolled in this trial. Twenty-five of them had nonsecreting pituitary tumors, 11 were acromegalic, and 6 had macro- or microprolactinoma. Scintigraphic images of the head were obtained at 10 min and 24 hours after injection of the radionuclide. In 23 patients, no specific binding of111In-octreotide was found. Five patients showed a weak positive, 5 had a positive, and 9 a strong positive signal in the region of interest. Uptake of octreotide was significantly correlated with tumor size and age (p < 0.01). Small-size pituitary adenomas were most likely to be scintigraphically receptor-negative, while large suprasellar tumors tended to exhibit a rather strong receptor positivity. Statistical analysis of the data could not confirm the hypothesized correlation between endocrine activity of the pituitary tumors and the scintigraphically proven SST receptor expressionin vivo. A positive Octreoscan was not predictive for the result of octreotide therapy. Walter de Gruyter & Co., 1997 Acromegaly nationallicence octreotide nationallicence pituitary adenoma nationallicence prolactinoma nationallicence scintigraphy nationallicence somatostatin nationallicence Rieger Andreas Department of Neurosurgery, Faculty of Medicine, Martin-Luther-University Halle-Wittenberg, Halle, Germany aut Rainov Nikolai Department of Neurosurgery, Justus-Liebig-University Gießen, Germany aut Elfrich Christiane Department of Neurosurgery, Justus-Liebig-University Gießen, Germany aut Klaua Monika Department of Nuclear Medicine, Faculty of Medicine, Martin-Luther-University Halle-Wittenberg, Germany aut Meyer Heike Department of Neurosurgery, Faculty of Medicine, Martin-Luther-University Halle-Wittenberg, Halle, Germany aut Lautenschläger Christine Institute for Biostatistics and Medical Informatics, Martin-Luther-University Halle-Wittenberg, Germany aut Burkert Winfried Department of Neurosurgery, Faculty of Medicine, Martin-Luther-University Halle-Wittenberg, Halle, Germany aut Mende Traute Department of Nuclear Medicine, Faculty of Medicine, Martin-Luther-University Halle-Wittenberg, Germany aut Neurosurgical Review Springer-Verlag 20/1(1997-03-01), 7-12 0344-5607 20:1<7 1997 20 10143 https://doi.org/10.1007/BF01390518 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01390518 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rieger Andreas Department of Neurosurgery, Faculty of Medicine, Martin-Luther-University Halle-Wittenberg, Halle, Germany aut NATIONALLICENCE 700 1- Rainov Nikolai Department of Neurosurgery, Justus-Liebig-University Gießen, Germany aut NATIONALLICENCE 700 1- Elfrich Christiane Department of Neurosurgery, Justus-Liebig-University Gießen, Germany aut NATIONALLICENCE 700 1- Klaua Monika Department of Nuclear Medicine, Faculty of Medicine, Martin-Luther-University Halle-Wittenberg, Germany aut NATIONALLICENCE 700 1- Meyer Heike Department of Neurosurgery, Faculty of Medicine, Martin-Luther-University Halle-Wittenberg, Halle, Germany aut NATIONALLICENCE 700 1- Lautenschläger Christine Institute for Biostatistics and Medical Informatics, Martin-Luther-University Halle-Wittenberg, Germany aut NATIONALLICENCE 700 1- Burkert Winfried Department of Neurosurgery, Faculty of Medicine, Martin-Luther-University Halle-Wittenberg, Halle, Germany aut NATIONALLICENCE 700 1- Mende Traute Department of Nuclear Medicine, Faculty of Medicine, Martin-Luther-University Halle-Wittenberg, Germany aut NATIONALLICENCE 773 0- Neurosurgical Review Springer-Verlag 20/1(1997-03-01), 7-12 0344-5607 20:1<7 1997 20 10143 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer