caa a22 4500 477139841 CHVBK 20180405111729.0 cr unu---uuuuu 170330e19970901xx s 000 0 eng 10.1007/BF01105562 doi (NATIONALLICENCE)springer-10.1007/BF01105562 Factors predicting pituitary adenoma invasiveness in acromegalic patients [Elektronische Daten] [Andreas Rieger, Nikolai Rainov, Heinrich Ebel, Lhagva Sanchin, Khalid Shibib, Christiane Helfrich, Olaf Hoffmann, Winfried Burkert] Forty-four adult acromegalic patients carrying growth hormone-producing pituitary macroadenomas were investigated with neuroradiological and endocrinological techniques. Plasma growth hormone and somatomedin-C levels were repeatedly measured before surgical removal of tumors and during the follow-up period. Twenty-five patients presented preoperatively with an invasive adenoma that involved the cavernous sinus (CS). Diagnosis of tumor invasivity was made according to distinct neuroradiological criteria and was confirmed or rejected during surgery. Significantly higher basal growth hormone levels were found in patients with CS invasion than in cases without tumor growth in the CS. Evidence is presented that plasma growth hormone level in acromegalics is a more sensitive indicator for predicting tumor invasiveness than somatomedin-C. Growth hormone basal values before surgery and the extent of their decrease after removal of tumor correlate with adenoma growth in the parasellar compartments and should be used as a prognostic factor to aid in planing adjuvant tumor treatment. Walter de Gruyter & Co., 1997 Acromegaly nationallicence cavernous sinus nationallicence growth hormone nationallicence pituitary adenoma nationallicence transsphenoidal surgery nationallicence Rieger Andreas Department of Neurosurgery, Martin-Luther-University Halle, Magdeburger Str. 16, D-06097, Halle/Saale, Germany aut Rainov Nikolai Department of Neurosurgery, Martin-Luther-University Halle, Magdeburger Str. 16, D-06097, Halle/Saale, Germany aut Ebel Heinrich Neurosurgical Clinic, Medical Faculty, Justus-Liebig-University, Gießen aut Sanchin Lhagva Department of Neurosurgery, Martin-Luther-University Halle, Magdeburger Str. 16, D-06097, Halle/Saale, Germany aut Shibib Khalid Department of Neurosurgery, Martin-Luther-University Halle, Magdeburger Str. 16, D-06097, Halle/Saale, Germany aut Helfrich Christiane Neurosurgical Clinic, Medical Faculty, Justus-Liebig-University, Gießen aut Hoffmann Olaf Division for Medical Information, Medical College Gießen, Germany aut Burkert Winfried Department of Neurosurgery, Martin-Luther-University Halle, Magdeburger Str. 16, D-06097, Halle/Saale, Germany aut Neurosurgical Review Springer-Verlag 20/3(1997-09-01), 182-187 0344-5607 20:3<182 1997 20 10143 https://doi.org/10.1007/BF01105562 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01105562 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rieger Andreas Department of Neurosurgery, Martin-Luther-University Halle, Magdeburger Str. 16, D-06097, Halle/Saale, Germany aut NATIONALLICENCE 700 1- Rainov Nikolai Department of Neurosurgery, Martin-Luther-University Halle, Magdeburger Str. 16, D-06097, Halle/Saale, Germany aut NATIONALLICENCE 700 1- Ebel Heinrich Neurosurgical Clinic, Medical Faculty, Justus-Liebig-University, Gießen aut NATIONALLICENCE 700 1- Sanchin Lhagva Department of Neurosurgery, Martin-Luther-University Halle, Magdeburger Str. 16, D-06097, Halle/Saale, Germany aut NATIONALLICENCE 700 1- Shibib Khalid Department of Neurosurgery, Martin-Luther-University Halle, Magdeburger Str. 16, D-06097, Halle/Saale, Germany aut NATIONALLICENCE 700 1- Helfrich Christiane Neurosurgical Clinic, Medical Faculty, Justus-Liebig-University, Gießen aut NATIONALLICENCE 700 1- Hoffmann Olaf Division for Medical Information, Medical College Gießen, Germany aut NATIONALLICENCE 700 1- Burkert Winfried Department of Neurosurgery, Martin-Luther-University Halle, Magdeburger Str. 16, D-06097, Halle/Saale, Germany aut NATIONALLICENCE 773 0- Neurosurgical Review Springer-Verlag 20/3(1997-09-01), 182-187 0344-5607 20:3<182 1997 20 10143 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer