caa a22 4500 477139981 CHVBK 20180405111730.0 cr unu---uuuuu 170330e19971201xx s 000 0 eng 10.1007/BF01105896 doi (NATIONALLICENCE)springer-10.1007/BF01105896 Comparison of microsuturing to the use of tissue adhesives in anastomosing sciatic nerve cuts in rats [Elektronische Daten] [Serap Inalöz, Hüseyin Ak, Vildan Vayla, Mehmet Akin, Adem Aslan, Ibrahim Sari, Yusuf Çelik, Ümit Özkan] The purpose of this study was to investigate and to compare the effects of microsuturing to that of tissue adhesives (Tisseel®) on the healing of anastomosing peripheral nerve incisions. Forty-five Wistar-Albino rats were placed in special cages and separated into three groups (n = 15). In the control group, biliteral sciatic nerves were explored but no incision was made. In the first experimental group, bilateral sciatic nerves were incised and end-to-end anastomosing was performed by microsuturing the epineurium. In the second experimental group, tissue adhesive (Tisseel®) was used alone in anastomosing the sciatic nerve cuts. Assessments of the healing processes were demonstrated by 1. electromyography (EMG), 2. measuring the electrical responses of the anastomosed nerves after electrical stimuli, 3. histopathological examination. Statistical analysis of the EMG findings showed that the Tisseel group was the closest in the healing process to the control group. After applying electrical stimuli to the dissected nerves, the resistance value of the Tisseel group was nearest to those of the control group. The histopathological examinations showed highly degenerative nervebundles and prominent foreign body granuloma at the anastomosed sites of the microsutured group. The granulomatous inflammation was observed to be much less in the Tisseel group. We conclude that the healing effect of Tisseel was found to be superior to that of microsmuring as demonstrated by the findings of EMG, electrical responses of the anastomosed nerves, and histopathological examination. Walter de Gruyter & Co., 1997 Histopathology nationallicence microsurgery nationallicence sciatic nerve nationallicence Tisseel nationallicence Inalöz Serap Department of Histology and Embryology, Dicle University Medical Faculty, Diyarbakir, Turkey aut Ak Hüseyin Department of Neurosurgery, Dicle University Medical Faculty, Diyarbakir, Turkey aut Vayla Vildan Department of Neurology, Dicle University Medical Faculty, Diyarbakir, Turkey aut Akin Mehmet Department of Physics, Dicle University Medical Faculty, Diyarbakir, Turkey aut Aslan Adem Department of Pathology, Dicle University Medical Faculty, Diyarbakir, Turkey aut Sari Ibrahim Department of Pathology, Dicle University Medical Faculty, Diyarbakir, Turkey aut Çelik Yusuf Department of Biostatics, Dicle University Medical Faculty, Diyarbakir, Turkey aut Özkan Ümit Department of Neurosurgery, Dicle University Medical Faculty, Diyarbakir, Turkey aut Neurosurgical Review Springer-Verlag 20/4(1997-12-01), 250-258 0344-5607 20:4<250 1997 20 10143 https://doi.org/10.1007/BF01105896 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01105896 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Inalöz Serap Department of Histology and Embryology, Dicle University Medical Faculty, Diyarbakir, Turkey aut NATIONALLICENCE 700 1- Ak Hüseyin Department of Neurosurgery, Dicle University Medical Faculty, Diyarbakir, Turkey aut NATIONALLICENCE 700 1- Vayla Vildan Department of Neurology, Dicle University Medical Faculty, Diyarbakir, Turkey aut NATIONALLICENCE 700 1- Akin Mehmet Department of Physics, Dicle University Medical Faculty, Diyarbakir, Turkey aut NATIONALLICENCE 700 1- Aslan Adem Department of Pathology, Dicle University Medical Faculty, Diyarbakir, Turkey aut NATIONALLICENCE 700 1- Sari Ibrahim Department of Pathology, Dicle University Medical Faculty, Diyarbakir, Turkey aut NATIONALLICENCE 700 1- Çelik Yusuf Department of Biostatics, Dicle University Medical Faculty, Diyarbakir, Turkey aut NATIONALLICENCE 700 1- Özkan Ümit Department of Neurosurgery, Dicle University Medical Faculty, Diyarbakir, Turkey aut NATIONALLICENCE 773 0- Neurosurgical Review Springer-Verlag 20/4(1997-12-01), 250-258 0344-5607 20:4<250 1997 20 10143 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer