caa a22 4500 477140114 CHVBK 20180405111730.0 cr unu---uuuuu 170330e19971201xx s 000 0 eng 10.1007/BF01105897 doi (NATIONALLICENCE)springer-10.1007/BF01105897 On the effect of calcium antagonists on cerebral blood flow in rats. A comparison of nimodipine and flunarizine [Elektronische Daten] [Matthias Zumkeller, Hans Heissler, Hermann Dietz] To assess the influence of nimodipine treatment in brain tissue at different levels of blood pressure, we estimated the cerebral blood flow using hydrogen clearance. Rats were treated with nimodipine (n = 8), its placebo (n = 10), flunarizine (n = 11) and its placebo (n = 10), and a group of controls (n =10). Cerebral blood flow was estimated during arterial normo-, hyper-and hypotension. The lowest cerebral blood flow estimates calculated for nimodipine were 43.8 ± 7.8, 90.9 ± 13.3, and 33.6 ± 6.1 ml/min/100 g for normo-, hyper- and hypotension, respectively. Cerebral blood flow in the nimodipine placebo group was 84.1 ±10.3,139.9 ± 19.9, and 55.2 ± 10.5 ml/min/100 g. In the flunarizine group, the blood flow was 77.3 ± 15.2,144.7 ± 15.0, and 43.8 ± 5.9 ml/min/100 g. In the control group, cerebral blood flow was 90.0 ± 29.1, 143.0 ± 42.1, and 75.5 ± 29.8 ml/min/100 g. The low blood flow in the nimodipine group might have been a consequence of brain edema caused by extravasates. Thus impaired blood flow reduces the usefulness of nimodipine in the prevention of vasospasm. Flunarizine is a potential alternative treatment of vasospasm treatment as well as for cerebral blood flow improvement, as shown in our experimental study. Walter de Gruyter & Co., 1997 Flunarizine nationallicence nimodipine nationallicence cerebral blood flow nationallicence induced hypertension nationallicence Zumkeller Matthias Neurochirurgische Klinik, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, D-30625, Hannover, Germany aut Heissler Hans Neurochirurgische Klinik, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, D-30625, Hannover, Germany aut Dietz Hermann Neurochirurgische Klinik, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, D-30625, Hannover, Germany aut Neurosurgical Review Springer-Verlag 20/4(1997-12-01), 259-268 0344-5607 20:4<259 1997 20 10143 https://doi.org/10.1007/BF01105897 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01105897 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zumkeller Matthias Neurochirurgische Klinik, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, D-30625, Hannover, Germany aut NATIONALLICENCE 700 1- Heissler Hans Neurochirurgische Klinik, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, D-30625, Hannover, Germany aut NATIONALLICENCE 700 1- Dietz Hermann Neurochirurgische Klinik, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, D-30625, Hannover, Germany aut NATIONALLICENCE 773 0- Neurosurgical Review Springer-Verlag 20/4(1997-12-01), 259-268 0344-5607 20:4<259 1997 20 10143 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer