caa a22 4500 477140548 CHVBK 20180405111731.0 cr unu---uuuuu 170330e19971101xx s 000 0 eng 10.1007/s002850050089 doi (NATIONALLICENCE)springer-10.1007/s002850050089 Ottesen Johnny T. IMFUFA, Roskilde University, Postbox 260, DK-4000 Roskilde, Denmark E-mail: Johnny@mmf.ruc.dk, DK aut Modelling of the baroreflex-feedback mechanism with time-delay [Elektronische Daten] [Johnny T. Ottesen] Abstract.:  The cardiovascular system is considered. A direct modelling of the non-linear baroreflex-feedback mechanism, including time-delay, is developed based on physiological theory and empirical facts. The feedback model is then evaluated on an expanded, but simple, non-pulsatile Windkessel model of the cardiovascular system. The stability of the entire model is analyzed and the effect of the value of the time-delay is investigated and discussed. The time-delay may cause oscillations. A finite number of stability switches may occur dependent on the value of the time-delay. The location of these stability switches turns out to be sensitive to the value of the parameters in the model. We suggest a simple experiment to determine whether or not the time-delay is responsible for the 10 second Mayer waves. Data from an ergometer bicycle test is used for evaluation of the model. Springer-Verlag Berlin Heidelberg, 1997 Key words: Cardiovascular system nationallicence Nonlinear baroreflex-feedback nationallicence Time-delay nationallicence Stability analysis nationallicence https://doi.org/10.1007/s002850050089 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002850050089 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Ottesen Johnny T. IMFUFA, Roskilde University, Postbox 260, DK-4000 Roskilde, Denmark E-mail: Johnny@mmf.ruc.dk, DK aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer