naa a22 4500 510727557 CHVBK 20180411082941.0 cr unu---uuuuu 180411e20130101xx s 000 0 eng 10.1007/s11748-012-0153-9 doi (NATIONALLICENCE)springer-10.1007/s11748-012-0153-9 Sawa Yoshiki Department of Cardiovascular Surgery, Graduate School of Medicine, Osaka University, 2-2, Yamada-Oka, 565-0871, Suita, Osaka, Japan aut Current status of myocardial regeneration therapy [Elektronische Daten] [Yoshiki Sawa] Myocardial regeneration therapy has emerged as an alternative therapy for heart failure and is expected to replace current conventional therapies. As a cell source, the presence of resident cardiac stem cells (RCSC) in the heart has been reported by many researchers. These RCSC show multi-potency and are considered to differentiate into myocytes. On the other hand, bone marrow stem cells have received the greatest attention as a source of cell transplantation therapy in the current era, with a larger number of clinical applications reported because of their ease and safety. Myoblasts have also emerged as a possible cell source for clinical applications. We previously found that myoblast-cell-sheet implantation improved cardiac function and ventricle thickness in a rat MI model. Furthermore, we conducted a pre-clinical large animal study using porcine MI and dog DCM models, and confirmed the effectiveness of skeletal myoblast sheets. Thereafter, we conducted clinical applications of skeletal myoblast implantation. It may eventually be possible to perform regeneration therapy as a routine therapeutic method. The Japanese Association for Thoracic Surgery, 2012 Myocardial regeneration therapy nationallicence Myoblast sheet nationallicence General Thoracic and Cardiovascular Surgery Springer Japan 61/1(2013-01-01), 17-23 1863-6705 61:1<17 2013 61 11748 https://doi.org/10.1007/s11748-012-0153-9 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11748-012-0153-9 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Sawa Yoshiki Department of Cardiovascular Surgery, Graduate School of Medicine, Osaka University, 2-2, Yamada-Oka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 773 0- General Thoracic and Cardiovascular Surgery Springer Japan 61/1(2013-01-01), 17-23 1863-6705 61:1<17 2013 61 11748 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer