naa a22 4500 510727883 CHVBK 20180411082942.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s11748-013-0263-z doi (NATIONALLICENCE)springer-10.1007/s11748-013-0263-z Validation of EBUS-TBNA-integrated nodal staging in potentially node-positive non-small cell lung cancer [Elektronische Daten] [Yuichi Sakairi, Hidehisa Hoshino, Taiki Fujiwara, Takahiro Nakajima, Kazuhiro Yasufuku, Shigetoshi Yoshida, Ichiro Yoshino] Objective: Nodal staging of lung cancer is important for selecting surgical candidates. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) was evaluated as a modality for nodal staging of patients with potentially node-positive non-small cell lung cancer (NSCLC). Methods: Endobronchial ultrasound-guided transbronchial needle aspiration was used for nodal staging of NSCLC patients with radiological N2/3 disease (short axis >10mm on computed tomography and/or standardized positron emission uptake value >2.5 on 2-deoxy-2[F-18] fluoro-d-glucose positron emission tomography), T-stage≥T2, or positive serum carcinoembryonic antigen. Data on eligible patients were extracted from the database of our institution and analyzed for differences in nodal stages between radiological staging (RS) and EBUS-TBNA-integrated staging (ES), with validation by pathological staging of patients who had undergone surgery. Results: Of 480 eligible patients, there were 135 N0/1 and 345 N2/3 patients according to RS. Out of the 345 patients staged as N2/3 by RS, 113 (33%) were downgraded to N0/1 by ES. Out of the 135 patients staged as N0/1 by RS, 12 (9%) were upgraded to N2/3 by ES. Patients were restaged as N0/1 in 236 cases and N2/3 in 244 cases by ES, and the distributions of nodal stage between RS and ES were significantly different (p<0.001). Finally, 215 out of the 236 ES-N0/1 patients underwent lung resection, and 195 (90.7%) and 20 patients were staged by pathology as N0/1 and N2, respectively. Conclusions: Endobronchial ultrasound-guided transbronchial needle aspiration is more accurate for lymph node staging compared to radiological staging. EBUS-TBNA can identify patients who are true candidates for surgery. The Author(s), 2013 EBUS-TBNA nationallicence Staging nationallicence Lung cancer nationallicence FDG-PET nationallicence Lymph nodes nationallicence Sakairi Yuichi Department of General Thoracic Surgery, Chiba University Graduate School of Medicine, 1-8-1, Inohana, 260-8670, Chiba, Japan aut Hoshino Hidehisa Department of General Thoracic Surgery, Chiba University Graduate School of Medicine, 1-8-1, Inohana, 260-8670, Chiba, Japan aut Fujiwara Taiki Department of General Thoracic Surgery, Chiba University Graduate School of Medicine, 1-8-1, Inohana, 260-8670, Chiba, Japan aut Nakajima Takahiro Department of General Thoracic Surgery, Chiba University Graduate School of Medicine, 1-8-1, Inohana, 260-8670, Chiba, Japan aut Yasufuku Kazuhiro Division of Thoracic Surgery, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada aut Yoshida Shigetoshi Department of General Thoracic Surgery, Chiba University Graduate School of Medicine, 1-8-1, Inohana, 260-8670, Chiba, Japan aut Yoshino Ichiro Department of General Thoracic Surgery, Chiba University Graduate School of Medicine, 1-8-1, Inohana, 260-8670, Chiba, Japan aut General Thoracic and Cardiovascular Surgery Springer Japan 61/9(2013-09-01), 522-527 1863-6705 61:9<522 2013 61 11748 https://doi.org/10.1007/s11748-013-0263-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11748-013-0263-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sakairi Yuichi Department of General Thoracic Surgery, Chiba University Graduate School of Medicine, 1-8-1, Inohana, 260-8670, Chiba, Japan aut NATIONALLICENCE 700 1- Hoshino Hidehisa Department of General Thoracic Surgery, Chiba University Graduate School of Medicine, 1-8-1, Inohana, 260-8670, Chiba, Japan aut NATIONALLICENCE 700 1- Fujiwara Taiki Department of General Thoracic Surgery, Chiba University Graduate School of Medicine, 1-8-1, Inohana, 260-8670, Chiba, Japan aut NATIONALLICENCE 700 1- Nakajima Takahiro Department of General Thoracic Surgery, Chiba University Graduate School of Medicine, 1-8-1, Inohana, 260-8670, Chiba, Japan aut NATIONALLICENCE 700 1- Yasufuku Kazuhiro Division of Thoracic Surgery, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada aut NATIONALLICENCE 700 1- Yoshida Shigetoshi Department of General Thoracic Surgery, Chiba University Graduate School of Medicine, 1-8-1, Inohana, 260-8670, Chiba, Japan aut NATIONALLICENCE 700 1- Yoshino Ichiro Department of General Thoracic Surgery, Chiba University Graduate School of Medicine, 1-8-1, Inohana, 260-8670, Chiba, Japan aut NATIONALLICENCE 773 0- General Thoracic and Cardiovascular Surgery Springer Japan 61/9(2013-09-01), 522-527 1863-6705 61:9<522 2013 61 11748 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer