naa a22 4500 510728162 CHVBK 20180411082943.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s11748-012-0181-5 doi (NATIONALLICENCE)springer-10.1007/s11748-012-0181-5 Destination therapy: the new gold standard treatment for heart failure patients with left ventricular assist devices [Elektronische Daten] [Michael Yamakawa, Shunei Kyo, Sean Yamakawa, Minoru Ono, Koichiro Kinugawa, Takashi Nishimura] Heart failure continues to be a growing health problem, eluding large-scale improvement and treatment. Cardiac transplantation has been the gold standard treatment with high post-transplant survival rates and relatively good quality of life. However, there has been an extreme shortage of organ donations, limiting transplants to only a very small portion of patients with the condition. This led to a growing interest in alternative options for the increasing population of patients who are waitlisted or ineligible for transplantation. In recent years, ventricular assist device (VAD) technologies have advanced from pulsatile blood pumps to continuous-flow pumps that have demonstrated unprecedented post-implantation survival rates. The HeartMate II, the only commercially available, continuous flow left ventricular assist device (LVAD) in the United States and Europe, has been implanted in over 10,000 patients worldwide, setting a benchmark for biomedical modalities of advanced heart failure treatment. Thanks to the successes of contemporary LVADs, patients are able to enjoy a better lifestyle, with a significantly prolonged life span and the ability to regularly partake in physical activities. In this new biomedical generation, the usage of LVADs has begun to expand towards the treatment for a wider range of heart conditions, including earlier stages of heart failure. In fact, LVAD implantations have surpassed the number of transplants taken place annually. An increasing number of patients are considering the permanent, circulatory support with an LVAD, namely destination therapy, as a promising option for treating heart failure. The Japanese Association for Thoracic Surgery, 2012 Left ventricular assist device nationallicence Destination therapy nationallicence Heart transplantation nationallicence Bridge-to-transplantation nationallicence Heart failure nationallicence Yamakawa Michael Department of Therapeutic Strategy for Heart Failure, University of Tokyo Hospital, Tokyo, Japan aut Kyo Shunei Department of Therapeutic Strategy for Heart Failure, University of Tokyo Hospital, Tokyo, Japan aut Yamakawa Sean Department of Therapeutic Strategy for Heart Failure, University of Tokyo Hospital, Tokyo, Japan aut Ono Minoru Department of Cardiothoracic Surgery, University of Tokyo Hospital, Tokyo, Japan aut Kinugawa Koichiro Department of Therapeutic Strategy for Heart Failure, University of Tokyo Hospital, Tokyo, Japan aut Nishimura Takashi Department of Therapeutic Strategy for Heart Failure, University of Tokyo Hospital, Tokyo, Japan aut General Thoracic and Cardiovascular Surgery Springer Japan 61/3(2013-03-01), 111-117 1863-6705 61:3<111 2013 61 11748 https://doi.org/10.1007/s11748-012-0181-5 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11748-012-0181-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yamakawa Michael Department of Therapeutic Strategy for Heart Failure, University of Tokyo Hospital, Tokyo, Japan aut NATIONALLICENCE 700 1- Kyo Shunei Department of Therapeutic Strategy for Heart Failure, University of Tokyo Hospital, Tokyo, Japan aut NATIONALLICENCE 700 1- Yamakawa Sean Department of Therapeutic Strategy for Heart Failure, University of Tokyo Hospital, Tokyo, Japan aut NATIONALLICENCE 700 1- Ono Minoru Department of Cardiothoracic Surgery, University of Tokyo Hospital, Tokyo, Japan aut NATIONALLICENCE 700 1- Kinugawa Koichiro Department of Therapeutic Strategy for Heart Failure, University of Tokyo Hospital, Tokyo, Japan aut NATIONALLICENCE 700 1- Nishimura Takashi Department of Therapeutic Strategy for Heart Failure, University of Tokyo Hospital, Tokyo, Japan aut NATIONALLICENCE 773 0- General Thoracic and Cardiovascular Surgery Springer Japan 61/3(2013-03-01), 111-117 1863-6705 61:3<111 2013 61 11748 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer