naa a22 4500 510728588 CHVBK 20180411082944.0 cr unu---uuuuu 180411e20130801xx s 000 0 eng 10.1007/s11748-013-0206-8 doi (NATIONALLICENCE)springer-10.1007/s11748-013-0206-8 Clinical benefits of methylprednisolone in off-pump coronary artery bypass surgery [Elektronische Daten] [Takanori Suezawa, Atsushi Aoki, Mitsuhisa Kotani, Mamoru Tago, Osamu Kobayashi, Akihito Hirasaki, Minako Sano, Nana Kameda, Hiroki Mitsunaka] Background: It has not been established whether off-pump coronary artery bypass grafting (OPCABG) is less invasive than conventional CABG. In our experience, OPCABG has several advantages such as shorter operative duration, decreased requirement of blood transfusion and myocardial protection compared with conventional CABG. However, frequency of postoperative paroxysmal atrial fibrillation (PAF) is similar between these techniques and early postoperative C-reactive protein (CRP) levels have been shown to be significantly higher in OPCABG. We hypothesized that preoperative steroid administration, routinely used only in conventional CABG, may alleviate high postoperative PAF and CRP levels. Therefore, a prospective, double-blind, clinical trial was conducted in OPCABG patients to investigate the clinical effects of preoperative steroid administration. Methods: Thirty OPCABG patients were randomly divided into 2 groups: control (Group C: n=15) and methylprednisolone (Group M: n=15) groups. Group M patients were intravenously administered 1000mg methylprednisolone during anesthesia induction. Results: Hospital death and infectious complication such as mediastinitis were not observed in either group. Postoperative PAF occurred in 47% (7/15) of patients in group C but in only 1 patient in group M (7%, P=0.013). Early postoperative CRP levels were significantly lower in group M than in group C (peak values on postoperative day 2: group M 15±6mg/dL vs. group C 23±4mg/dL; P=0.0002). Conclusions: Preoperative steroid administration in OPCABG patients significantly suppresses CRP elevation and prevents postoperative PAF without increasing in-hospital mortality or infectious complications. The Japanese Association for Thoracic Surgery, 2013 Off-pump coronary artery bypass nationallicence Methylprednisolone nationallicence Atrial fibrillation nationallicence Inflammation nationallicence Suezawa Takanori Department of Cardiovascular Surgery, Kagawa Prefectural Central Hospital, 5-4-16 Ban-cho, 760-8557, Takamatsu, Kagawa, Japan aut Aoki Atsushi Department of Cardiovascular Surgery, Kagawa Prefectural Central Hospital, 5-4-16 Ban-cho, 760-8557, Takamatsu, Kagawa, Japan aut Kotani Mitsuhisa Department of Cardiovascular Surgery, Kagawa Prefectural Central Hospital, 5-4-16 Ban-cho, 760-8557, Takamatsu, Kagawa, Japan aut Tago Mamoru Department of Cardiovascular Surgery, Kagawa Prefectural Central Hospital, 5-4-16 Ban-cho, 760-8557, Takamatsu, Kagawa, Japan aut Kobayashi Osamu Department of Anesthesiology, Kagawa Prefectural Central Hospital, Takamatsu, Kagawa, Japan aut Hirasaki Akihito Department of Anesthesiology, Kagawa Prefectural Central Hospital, Takamatsu, Kagawa, Japan aut Sano Minako Department of Anesthesiology, Kagawa Prefectural Central Hospital, Takamatsu, Kagawa, Japan aut Kameda Nana Department of Anesthesiology, Kagawa Prefectural Central Hospital, Takamatsu, Kagawa, Japan aut Mitsunaka Hiroki Department of Rheumatology, Kagawa Prefectural Central Hospital, Takamatsu, Kagawa, Japan aut General Thoracic and Cardiovascular Surgery Springer Japan 61/8(2013-08-01), 455-459 1863-6705 61:8<455 2013 61 11748 https://doi.org/10.1007/s11748-013-0206-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11748-013-0206-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Suezawa Takanori Department of Cardiovascular Surgery, Kagawa Prefectural Central Hospital, 5-4-16 Ban-cho, 760-8557, Takamatsu, Kagawa, Japan aut NATIONALLICENCE 700 1- Aoki Atsushi Department of Cardiovascular Surgery, Kagawa Prefectural Central Hospital, 5-4-16 Ban-cho, 760-8557, Takamatsu, Kagawa, Japan aut NATIONALLICENCE 700 1- Kotani Mitsuhisa Department of Cardiovascular Surgery, Kagawa Prefectural Central Hospital, 5-4-16 Ban-cho, 760-8557, Takamatsu, Kagawa, Japan aut NATIONALLICENCE 700 1- Tago Mamoru Department of Cardiovascular Surgery, Kagawa Prefectural Central Hospital, 5-4-16 Ban-cho, 760-8557, Takamatsu, Kagawa, Japan aut NATIONALLICENCE 700 1- Kobayashi Osamu Department of Anesthesiology, Kagawa Prefectural Central Hospital, Takamatsu, Kagawa, Japan aut NATIONALLICENCE 700 1- Hirasaki Akihito Department of Anesthesiology, Kagawa Prefectural Central Hospital, Takamatsu, Kagawa, Japan aut NATIONALLICENCE 700 1- Sano Minako Department of Anesthesiology, Kagawa Prefectural Central Hospital, Takamatsu, Kagawa, Japan aut NATIONALLICENCE 700 1- Kameda Nana Department of Anesthesiology, Kagawa Prefectural Central Hospital, Takamatsu, Kagawa, Japan aut NATIONALLICENCE 700 1- Mitsunaka Hiroki Department of Rheumatology, Kagawa Prefectural Central Hospital, Takamatsu, Kagawa, Japan aut NATIONALLICENCE 773 0- General Thoracic and Cardiovascular Surgery Springer Japan 61/8(2013-08-01), 455-459 1863-6705 61:8<455 2013 61 11748 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer