naa a22 4500 510728650 CHVBK 20180411082944.0 cr unu---uuuuu 180411e20130501xx s 000 0 eng 10.1007/s11748-013-0235-3 doi (NATIONALLICENCE)springer-10.1007/s11748-013-0235-3 Epigenetic alterations and their clinical implications in esophageal squamous cell carcinoma [Elektronische Daten] [Yasushi Toh, Akinori Egashira, Manabu Yamamoto] Alterations in the regulation of gene expression that do not involve a change in the DNA sequence have been increasingly recognized as an important key event of carcinogenesis, referred to as "epigenetic” changes. Major epigenetic mechanisms include the methylation of cytosines in DNA, changes of histone and chromatin structure by covalent posttranslational modifications of histone proteins and alterations in the expression of microRNAs. These epigenetic alterations have also been identified in esophageal squamous cell carcinoma (ESCC). In this brief review, we will discuss DNA hypermethylation of the tumor suppressor gene promoters, histone modifications including histone acetylation/deacetylation and histone methylation and microRNAs in ESCC. Clinical implications of these epigenetic alterations in ESCC will be also discussed. The Japanese Association for Thoracic Surgery, 2013 Esophageal squamous cell carcinoma nationallicence Epigenetics nationallicence DNA methylation nationallicence Histone modification nationallicence MicroRNA nationallicence Clinical implications nationallicence Toh Yasushi Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3-1-1 Notame, Minami-ku, 811-1395, Fukuoka, Japan aut Egashira Akinori Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3-1-1 Notame, Minami-ku, 811-1395, Fukuoka, Japan aut Yamamoto Manabu Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3-1-1 Notame, Minami-ku, 811-1395, Fukuoka, Japan aut General Thoracic and Cardiovascular Surgery Springer Japan 61/5(2013-05-01), 262-269 1863-6705 61:5<262 2013 61 11748 https://doi.org/10.1007/s11748-013-0235-3 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11748-013-0235-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Toh Yasushi Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3-1-1 Notame, Minami-ku, 811-1395, Fukuoka, Japan aut NATIONALLICENCE 700 1- Egashira Akinori Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3-1-1 Notame, Minami-ku, 811-1395, Fukuoka, Japan aut NATIONALLICENCE 700 1- Yamamoto Manabu Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3-1-1 Notame, Minami-ku, 811-1395, Fukuoka, Japan aut NATIONALLICENCE 773 0- General Thoracic and Cardiovascular Surgery Springer Japan 61/5(2013-05-01), 262-269 1863-6705 61:5<262 2013 61 11748 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer