naa a22 4500 510728715 CHVBK 20180411082944.0 cr unu---uuuuu 180411e20130201xx s 000 0 eng 10.1007/s11748-012-0187-z doi (NATIONALLICENCE)springer-10.1007/s11748-012-0187-z Diagnostic reproducibility of thymic epithelial tumors using the World Health Organization classification: note for thoracic clinicians [Elektronische Daten] [Noriaki Sakakura, Hisashi Tateyama, Shigeo Nakamura, Tetsuo Taniguchi, Noriyasu Usami, Yoshinori Ishikawa, Koji Kawaguchi, Kohei Yokoi] Objective: Histopathological diagnosis of thymic epithelial tumors according to the current World Health Organization classification is not adequately reproducible; however, most thoracic clinicians are unaware of this. We illustrate this problem in practical settings to raise clinician awareness. Methods: An expert pathologist specialized in thymic pathology and a trained general pathologist independently diagnosed 158 resected thymic epithelial tumors. Assuming that the expert's diagnoses were more accurate, the two pathologists' diagnoses were judged to be concordant when tumor subtypes (thymoma) or categories (thymic carcinoma and neuroendocrine tumor) were in agreement. Results: The concordance rates for different thymoma subtypes were 75% (3/4), 30% (11/37), 100% (17/17), 80% (39/49), and 53% (9/17) for types A, AB, B1, B2, and B3, respectively. Discordant cases of type AB thymoma were mainly diagnosed as type B1 or B2 by the general pathologist. Discordant cases of type B2 thymoma were diagnosed as type AB, B1, or B3, and discordant cases of type B3 thymoma were diagnosed as type A, B2, or carcinoma. Discordant cases of thymic carcinoma were diagnosed as type A or B3 thymoma. Conclusion: Investigation of the concordant and discordant cases suggested that reasonable discrepancies can occur because of the noncommittal categorical boundaries inherent in this classification. Thoracic clinicians should consider this potential problem in daily practice. The Japanese Association for Thoracic Surgery, 2012 Thymoma nationallicence Thymic carcinoma nationallicence Diagnostic reproducibility nationallicence Classification nationallicence Sakakura Noriaki Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Aichi, Japan aut Tateyama Hisashi Department of Pathology, Kasugai Municipal Hospital, Kasugai, Japan aut Nakamura Shigeo Department of Pathology and Laboratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan aut Taniguchi Tetsuo Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Aichi, Japan aut Usami Noriyasu Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Aichi, Japan aut Ishikawa Yoshinori Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Aichi, Japan aut Kawaguchi Koji Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Aichi, Japan aut Yokoi Kohei Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Aichi, Japan aut General Thoracic and Cardiovascular Surgery Springer Japan 61/2(2013-02-01), 89-95 1863-6705 61:2<89 2013 61 11748 https://doi.org/10.1007/s11748-012-0187-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11748-012-0187-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sakakura Noriaki Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Aichi, Japan aut NATIONALLICENCE 700 1- Tateyama Hisashi Department of Pathology, Kasugai Municipal Hospital, Kasugai, Japan aut NATIONALLICENCE 700 1- Nakamura Shigeo Department of Pathology and Laboratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan aut NATIONALLICENCE 700 1- Taniguchi Tetsuo Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Aichi, Japan aut NATIONALLICENCE 700 1- Usami Noriyasu Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Aichi, Japan aut NATIONALLICENCE 700 1- Ishikawa Yoshinori Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Aichi, Japan aut NATIONALLICENCE 700 1- Kawaguchi Koji Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Aichi, Japan aut NATIONALLICENCE 700 1- Yokoi Kohei Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Aichi, Japan aut NATIONALLICENCE 773 0- General Thoracic and Cardiovascular Surgery Springer Japan 61/2(2013-02-01), 89-95 1863-6705 61:2<89 2013 61 11748 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer