naa a22 4500 510730086 CHVBK 20180411082949.0 cr unu---uuuuu 180411e20130601xx s 000 0 eng 10.1007/s12671-012-0178-2 doi (NATIONALLICENCE)springer-10.1007/s12671-012-0178-2 A Pilot Study of a Mindfulness Intervention for Individuals with Williams Syndrome: Physiological Outcomes [Elektronische Daten] [Nancy Miodrag, Miriam Lense, Elisabeth Dykens] Mindfulness-based interventions have received little attention in the world of intellectual and developmental disabilities. No studies have assessed the role of mindfulness practice in relation to Williams syndrome (WS)—a neurodevelopmental disorder associated with high rates of anxiety, and attentional and social difficulties. Our aim was to demonstrate the feasibility of a mindfulness intervention for adults with Williams syndrome. We examined the physiological [salivary cortisol and alpha-amylase (sAA)] responses following a brief, 5-day mindfulness intervention in 24 individuals with WS. We also evaluated how their psychological (self-reported anxiety) and behavioral (parent/caregiver reports of somatic complaints and attention problems) states related to these physiological outcomes. As a group, cortisol levels decreased each day following mindfulness sessions. Both cortisol and self-rated anxiety levels followed the same pattern across mindfulness sessions, with ratings declining in response to each session. sAA levels during sessions 1 and 2 were significantly higher than during sessions 4 and 5. Greater somatic problems significantly predicted higher cortisol levels during the mindfulness intervention, while greater CBCL Attention Problems significantly predicted lower sAA levels during the intervention. Our findings underscore the utility of mindfulness practice as a tool to reduce stress-related symptoms in persons with WS. Springer Science+Business Media New York, 2012 Williams syndrome nationallicence Mindfulness intervention nationallicence Salivary cortisol nationallicence Salivary alpha-amylase nationallicence Behavioral phenotype nationallicence Miodrag Nancy Department of Child and Adolescent Development, California State University, Northridge, 18111 Nordhoff Street, 91330-8263, Northridge, CA, USA aut Lense Miriam Vanderbilt Kennedy Center, Department of Psychology and Human Development, Vanderbilt University, TN, Nashville, USA aut Dykens Elisabeth Vanderbilt Kennedy Center; Department of Psychology and Human Development; Department of Psychiatry, Department of Pediatrics, Vanderbilt University, Nashville, TN, USA aut Mindfulness Springer US; http://www.springer-ny.com 4/2(2013-06-01), 137-147 1868-8527 4:2<137 2013 4 12671 https://doi.org/10.1007/s12671-012-0178-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12671-012-0178-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Miodrag Nancy Department of Child and Adolescent Development, California State University, Northridge, 18111 Nordhoff Street, 91330-8263, Northridge, CA, USA aut NATIONALLICENCE 700 1- Lense Miriam Vanderbilt Kennedy Center, Department of Psychology and Human Development, Vanderbilt University, TN, Nashville, USA aut NATIONALLICENCE 700 1- Dykens Elisabeth Vanderbilt Kennedy Center; Department of Psychology and Human Development; Department of Psychiatry, Department of Pediatrics, Vanderbilt University, Nashville, TN, USA aut NATIONALLICENCE 773 0- Mindfulness Springer US; http://www.springer-ny.com 4/2(2013-06-01), 137-147 1868-8527 4:2<137 2013 4 12671 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer