naa a22 4500 51073331X CHVBK 20180411083000.0 cr unu---uuuuu 180411e20130101xx s 000 0 eng 10.1007/s12039-012-0344-z doi (NATIONALLICENCE)springer-10.1007/s12039-012-0344-z Synthesis and evaluation of some bioactive compounds having oxygen and nitrogen heteroatom [Elektronische Daten] [POONAM YADAV, NALINI PUROHIT] Some new 3,4-disubstituted isocoumarins were synthesized having bioactive pyrazole molecule at 3rd position of isocoumarin moiety (5a,b), from isocoumarin -3- carboxylic acid hydrazide (4a,b) followed by cyclization with acetyl acetone. A series of isocoumarin derivative having Schiff base as lateral side chain at 3rd position of isocoumarin moiety were also synthesized (7a,b), by condensing isocoumarin acid hydrazide and benzaldehyde derivative followed by dehydration. The chemical structures of all the compounds were determined by analytical and spectral method. The lead compounds were screened for antimicrobial and analgesic activities. Graphical Abstract The article presents the synthesis and characterization of different isocoumarin derivatives from Isocoumarin-3-carboxylic acid hydrazide. The compounds were also screened for their antimicrobial and analgesic activities. Indian Academy of Sciences, 2013 Pyrazole isocoumarins nationallicence Schiff base isocoumarins nationallicence antibacterial activity nationallicence antifungal activity nationallicence analgesic activity nationallicence YADAV POONAM School of Science and Education, Navrachana University, 391 410, Vadodara, India aut PUROHIT NALINI Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, 390 002, Vadodara, India aut Journal of Chemical Sciences Springer-Verlag 125/1(2013-01-01), 165-173 0974-3626 125:1<165 2013 125 12039 https://doi.org/10.1007/s12039-012-0344-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12039-012-0344-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- YADAV POONAM School of Science and Education, Navrachana University, 391 410, Vadodara, India aut NATIONALLICENCE 700 1- PUROHIT NALINI Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, 390 002, Vadodara, India aut NATIONALLICENCE 773 0- Journal of Chemical Sciences Springer-Verlag 125/1(2013-01-01), 165-173 0974-3626 125:1<165 2013 125 12039 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer