naa a22 4500 510733360 CHVBK 20180411083000.0 cr unu---uuuuu 180411e20130101xx s 000 0 eng 10.1007/s12039-012-0352-z doi (NATIONALLICENCE)springer-10.1007/s12039-012-0352-z An eco-sustainable green approach for the synthesis of propargylamines using LiOTf as a reusable catalyst under solvent-free condition [Elektronische Daten] [SOMESHWAR DINDULKAR, BAEK KWAN, KWON LIM, YEON JEONG] An efficient process has been developed for the synthesis of propargylamines via a three-component coupling reaction of aldehyde, secondary alicyclic amine and alkyne (A3) under solvent-free condition using lithium triflate (LiOTf) as expeditious reusable catalyst. This one-pot transformation generates one C-C and one C-N bond, which presumably proceeds by lithium acetylide as well as formation of iminium ion in situ and then undergoes nucleophilic addition to the iminium ion to give the propargyl amine. The solvent-free condition, easy recovery of the catalyst, simple, user-friendly and quantitative yield in short time renders the protocol economic and reasonable. Graphical Abstract An efficient process has been developed for the synthesis of propargylamines via a three-component coupling reaction of aldehyde, secondary alicyclic amines and alkyne (A3) under solvent-free conditions using lithium triflate (LiOTf) as expeditious reusable catalyst. Indian Academy of Sciences, 2013 Lithium triflate (LiOTf) nationallicence three-component coupling (A3) nationallicence propargylamine nationallicence C-H activation nationallicence solvent-free condition nationallicence DINDULKAR SOMESHWAR Department of Image Science and Engineering, Pukyong National University, 608-739, Busan, Republic of Korea aut KWAN BAEK Department of Image Science and Engineering, Pukyong National University, 608-739, Busan, Republic of Korea aut LIM KWON Department of Image Science and Engineering, Pukyong National University, 608-739, Busan, Republic of Korea aut JEONG YEON Department of Image Science and Engineering, Pukyong National University, 608-739, Busan, Republic of Korea aut Journal of Chemical Sciences Springer-Verlag 125/1(2013-01-01), 101-107 0974-3626 125:1<101 2013 125 12039 https://doi.org/10.1007/s12039-012-0352-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12039-012-0352-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- DINDULKAR SOMESHWAR Department of Image Science and Engineering, Pukyong National University, 608-739, Busan, Republic of Korea aut NATIONALLICENCE 700 1- KWAN BAEK Department of Image Science and Engineering, Pukyong National University, 608-739, Busan, Republic of Korea aut NATIONALLICENCE 700 1- LIM KWON Department of Image Science and Engineering, Pukyong National University, 608-739, Busan, Republic of Korea aut NATIONALLICENCE 700 1- JEONG YEON Department of Image Science and Engineering, Pukyong National University, 608-739, Busan, Republic of Korea aut NATIONALLICENCE 773 0- Journal of Chemical Sciences Springer-Verlag 125/1(2013-01-01), 101-107 0974-3626 125:1<101 2013 125 12039 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer