naa a22 4500 510733409 CHVBK 20180411083001.0 cr unu---uuuuu 180411e20130101xx s 000 0 eng 10.1007/s12039-012-0325-2 doi (NATIONALLICENCE)springer-10.1007/s12039-012-0325-2 Super acid catalysed sequential hydrolysis/cycloisomerization of o -(acetylenic)benzamides under microwave condition: Synthesis, antinociceptive and antiinflammatory activity of substituted isocoumarins [Elektronische Daten] [CHANDRASEKARAN PRAVEEN, P DHEENKUMAR, P PERUMAL] Synthesis of isocoumarins and related compounds via triflic acid promoted hydrolysis/cyclization sequence of 2-(alkynyl)benzamides under microwave condition was achieved. The substrate scope of the reaction was broad to include not only aromatic but also polyaromatic and heteroaromatic motifs, thus highlighting the significance of this methodology. One-pot operation, short reaction time, good chemical yields and excellent regioselectivity are the advantages of this protocol. All the synthesized compounds were evaluated for their antinociceptive and antiinflammatory activities using in vivo rodent models. Graphical Abstract Synthesis of isocoumarins via triflic acid promoted sequential hydrolysis/cyclization of 2-(alkynyl)benzamides under microwave condition was achieved. All the synthesized compounds were evaluated for their antinociceptive and antiinflammatory activities using in vivo rodent models. Indian Academy of Sciences, 2012 Microwave nationallicence sequential process nationallicence isocoumarins nationallicence antinociceptive nationallicence antiinflammatory nationallicence PRAVEEN CHANDRASEKARAN Organic Chemistry Division, Central Leather Research Institute (CSIR), 600 020, Chennai, Adyar, India aut DHEENKUMAR P. Department of Pharmaceutical Chemistry, EGS Pillay College of Pharmacy, 611 002, Nagapattinam, India aut PERUMAL P. Organic Chemistry Division, Central Leather Research Institute (CSIR), 600 020, Chennai, Adyar, India aut Journal of Chemical Sciences Springer-Verlag 125/1(2013-01-01), 71-83 0974-3626 125:1<71 2013 125 12039 https://doi.org/10.1007/s12039-012-0325-2 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12039-012-0325-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- PRAVEEN CHANDRASEKARAN Organic Chemistry Division, Central Leather Research Institute (CSIR), 600 020, Chennai, Adyar, India aut NATIONALLICENCE 700 1- DHEENKUMAR P. Department of Pharmaceutical Chemistry, EGS Pillay College of Pharmacy, 611 002, Nagapattinam, India aut NATIONALLICENCE 700 1- PERUMAL P. Organic Chemistry Division, Central Leather Research Institute (CSIR), 600 020, Chennai, Adyar, India aut NATIONALLICENCE 773 0- Journal of Chemical Sciences Springer-Verlag 125/1(2013-01-01), 71-83 0974-3626 125:1<71 2013 125 12039 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer