naa a22 4500 510733441 CHVBK 20180411083001.0 cr unu---uuuuu 180411e20130101xx s 000 0 eng 10.1007/s12039-012-0354-x doi (NATIONALLICENCE)springer-10.1007/s12039-012-0354-x Synthesis of 2-(3-methyl-2-oxoquinoxalin-1(2 H )-yl)acetamide-based azetidinone derivatives as potent antibacterial and antifungal agents [Elektronische Daten] [SHIV KUMAR, NITIN KUMAR, SUSHMA DRABU, MD. MINHAJ] Twelve compounds belonging to series N-[3-chloro-2-oxo-4-(substituted)phenylazetidin-1-yl]-2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)acetamide (5a-l) were synthesized. These compounds were evaluated for their in vitro antibacterial against E. coli, S. aureus, K. pneumoniae, P. aeruginosa and antifungal activity against C. albicans, A. niger and A. flavus by cup-plate method. Structures of all the newly synthesized compounds were confirmed by their spectral data interpretation. Compound 5g having p-dimethylaminophenyl group on 4-position of azetidinone ring attached to N-atom of acetamido group on 1-position of 3-methyl-1H-quinoxaline-2-one, was found to be active against all the bacterial and fungal strains under investigation. Graphical Abstract A new series of compounds belonging to N-[3-chloro-2-oxo-4-(substituted) phenylazetidin-1-yl]-2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)acetamide was synthesized and all the newly synthesized compounds were evaluated for their in vitro antibacterial and antifungal activities. Indian Academy of Sciences, 2013 Quinoxaline nationallicence azetidinone nationallicence antibacterial nationallicence antifungal nationallicence KUMAR SHIV Division of Pharmaceutical Chemistry, Department of Pharmacy, IEC College of Engineering and Technology, Knowledge Park-I, 201 308, Greater Noida, India aut KUMAR NITIN Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, 250 005, Meerut, India aut DRABU SUSHMA Maharaja Surajmal Institute of Pharmacy, 110 058, Janak Puri, New Delhi, India aut MINHAJ MD Division of Pharmaceutical Chemistry, Department of Pharmacy, IEC College of Engineering and Technology, Knowledge Park-I, 201 308, Greater Noida, India aut Journal of Chemical Sciences Springer-Verlag 125/1(2013-01-01), 129-139 0974-3626 125:1<129 2013 125 12039 https://doi.org/10.1007/s12039-012-0354-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12039-012-0354-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- KUMAR SHIV Division of Pharmaceutical Chemistry, Department of Pharmacy, IEC College of Engineering and Technology, Knowledge Park-I, 201 308, Greater Noida, India aut NATIONALLICENCE 700 1- KUMAR NITIN Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, 250 005, Meerut, India aut NATIONALLICENCE 700 1- DRABU SUSHMA Maharaja Surajmal Institute of Pharmacy, 110 058, Janak Puri, New Delhi, India aut NATIONALLICENCE 700 1- MINHAJ MD Division of Pharmaceutical Chemistry, Department of Pharmacy, IEC College of Engineering and Technology, Knowledge Park-I, 201 308, Greater Noida, India aut NATIONALLICENCE 773 0- Journal of Chemical Sciences Springer-Verlag 125/1(2013-01-01), 129-139 0974-3626 125:1<129 2013 125 12039 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer