naa a22 4500 510733476 CHVBK 20180411083001.0 cr unu---uuuuu 180411e20130101xx s 000 0 eng 10.1007/s12039-013-0363-4 doi (NATIONALLICENCE)springer-10.1007/s12039-013-0363-4 An efficient synthesis and biological study of substituted 8-chloro-5-methoxy/8-chloro-4H-1,4-benzothiazines, their sulphones and ribofuranosides [Elektronische Daten] [NISHIDHA KHANDELWAL, ABHILASHA,, NAVEEN GAUTAM, D GAUTAM] 8-Chloro-5-methoxy/8-chloro-4H-1,4-benzothiazines were synthesized by condensation followed by oxidative cyclisation of 2-amino-6-chloro-3-methoxy/2-amino-3-chlorobenzenethiol with β-diketones/β-ketoesters in the presence of dimethyl sulphoxide. By treating 4H-1,4-benzothiazines with 30% hydrogen peroxide in glacial acetic acid, 4H-1,4-benzothiazine-1,1-dioxides (sulphones) were synthesized. The 4H-1,4-benzothiazines have also been used as a base to prepare ribofuranosides by the reaction with β-D-ribofuranose-1-acetate-2,3,5-tribenzoate. All the synthesized compounds have been characterized by spectral and elemental analysis and have been examined for antimicrobial and anthelmintic activity. Graphical Abstract 4H-1,4-benzothiazines, the nitrogen and sulphur containing heterocycles are prepared by condensation followed by oxidative cyclization of 2-aminobenzenethiols with β-diketones/β-ketoester in dimethylsulphoxide. These compounds were then used as base to prepare ribofuranosides and their sulphones. Indian Academy of Sciences, 2013 4H-1,4-benzothiazines nationallicence sulphones nationallicence ribofuranosides nationallicence antimicrobial activity nationallicence anthelmintic activity nationallicence KHANDELWAL NISHIDHA Department of Chemistry, University of Rajasthan, Jawahar LaL Nehru Marg, 302 004, Jaipur, India aut ABHILASHA, Department of Chemistry, University of Rajasthan, Jawahar LaL Nehru Marg, 302 004, Jaipur, India aut GAUTAM NAVEEN Department of Chemistry, University of Rajasthan, Jawahar LaL Nehru Marg, 302 004, Jaipur, India aut GAUTAM D. Department of Chemistry, University of Rajasthan, Jawahar LaL Nehru Marg, 302 004, Jaipur, India aut Journal of Chemical Sciences Springer-Verlag 125/1(2013-01-01), 85-93 0974-3626 125:1<85 2013 125 12039 https://doi.org/10.1007/s12039-013-0363-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12039-013-0363-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- KHANDELWAL NISHIDHA Department of Chemistry, University of Rajasthan, Jawahar LaL Nehru Marg, 302 004, Jaipur, India aut NATIONALLICENCE 700 1- ABHILASHA Department of Chemistry, University of Rajasthan, Jawahar LaL Nehru Marg, 302 004, Jaipur, India aut NATIONALLICENCE 700 1- GAUTAM NAVEEN Department of Chemistry, University of Rajasthan, Jawahar LaL Nehru Marg, 302 004, Jaipur, India aut NATIONALLICENCE 700 1- GAUTAM D. Department of Chemistry, University of Rajasthan, Jawahar LaL Nehru Marg, 302 004, Jaipur, India aut NATIONALLICENCE 773 0- Journal of Chemical Sciences Springer-Verlag 125/1(2013-01-01), 85-93 0974-3626 125:1<85 2013 125 12039 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer