naa a22 4500 510733603 CHVBK 20180411083001.0 cr unu---uuuuu 180411e20131101xx s 000 0 eng 10.1007/s12039-013-0529-0 doi (NATIONALLICENCE)springer-10.1007/s12039-013-0529-0 Bis-(1 H -2-benzopyran-1-one) derivatives: Synthesis and antimicrobial evaluation [Elektronische Daten] [POONAM KOPPULA, NALINI PUROHIT] The aim of the present study was to synthesize isocoumarin heterocycles and to elucidate the potential role of these compounds as biological active agents. A new series of isocoumarin derivatives containing two six-membered lactone rings is reported. 3-Aroyl-substituted isocoumarins (3) obtained by condensing 2- carboxy benzaldehyde (1) with bromoacetophenone derivatives (2) was further reacted with different aromatic aldehydes (4) affording bis-(1H-2-benzopyran-1-one) derivatives (5). This short review compiles examples of most promising antibacterial, antifungal and analgesic bis-(1H-2-benzopyran-1-one) derivatives. The products were characterized on the basis of analytical and spectral (IR, 1HNMR, C13NMR, Mass) data. The biological activity study revealed that all compounds showed promising activities and bis-(1H-2-benzopyran-1-one) derivatives (5) were found to be more active than 3-aroyl-substituted isocoumarins (3). Graphical Abstract New bis-(1H-2-benzopyran-1-one) derivatives (5a-m) were synthesized by condensing 3-aroyl isocoumarins (3a-f) with different aromatic aldehydes (4). Chemical structures of all the compounds were determined by analytical and spectral methods. Lead compounds were screened for antimicrobial and analgesic activities. Indian Academy of Sciences, 2013 2-Carboxy benzaldehyde nationallicence 3-aroyl isocoumarin nationallicence bis-(1 H -2-benzopyran-1-one) derivatives nationallicence antibacterial activity nationallicence antifungal activity nationallicence analgesic activity nationallicence KOPPULA POONAM School of Science and Education, Navrachana University, 391 410, Vadodara, India aut PUROHIT NALINI Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, 390 002, Vadodara, India aut Journal of Chemical Sciences Springer India 125/6(2013-11-01), 1535-1542 0974-3626 125:6<1535 2013 125 12039 https://doi.org/10.1007/s12039-013-0529-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12039-013-0529-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- KOPPULA POONAM School of Science and Education, Navrachana University, 391 410, Vadodara, India aut NATIONALLICENCE 700 1- PUROHIT NALINI Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, 390 002, Vadodara, India aut NATIONALLICENCE 773 0- Journal of Chemical Sciences Springer India 125/6(2013-11-01), 1535-1542 0974-3626 125:6<1535 2013 125 12039 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer