naa a22 4500 510733727 CHVBK 20180411083002.0 cr unu---uuuuu 180411e20131101xx s 000 0 eng 10.1007/s12039-013-0528-1 doi (NATIONALLICENCE)springer-10.1007/s12039-013-0528-1 Synthesis, structural characterization and biological activity of a trinuclear zinc(II) complex: DNA interaction study and antimicrobial activity [Elektronische Daten] [BHASKAR BISWAS, NIRANJAN KOLE, MOUMITA PATRA, SHAMPA DUTTA, MOUSUMI GANGULY] A trinuclear zinc(II) complex [Zn3 L 2(μ-O2CCH3)2(H2O)2]·H2O·2CH3OH (1) was synthesized from an in situ reaction between zinc acetate and a Schiff base ligand (H2 L = 2-((2-hydroxyphenylimino)methyl)-6-methoxyphenol). The ligand was prepared by (1:1) condensation of ortho-vanillin and ortho-aminophenol. The ligand and zinc(II) complex were characterized by elemental analysis, Fourier Transform Infrared (FTIR), 1H-Nuclear Magnetic Resonance (NMR), UV-Vis spectroscopy, Powder X-ray Diffraction (PXRD) and thermogravimetric analysis. 1 crystallizes in P-1 space group with a = 11.9241(3) Å, b = 12.19746 Å, c = 20.47784 Å with unit cell volume is 2674.440 (Å)3. Binding property of the complex with calf thymus DNA (CT-DNA) has been investigated using absorption and emission studies. Thermal melting and viscosity experiments were further performed to determine the mode of binding of 1 with CT-DNA. Spectroscopic and viscosity investigations revealed an intercalative binding mode of 1 with CT-DNA. The ligand and its zinc complex were screened for their biological activity against bacterial species and fungi. Activity data show that the metal complex has more antibacterial and antifungal activity than the parent Schiff base ligand and against those bacterial or fungi species. Graphical Abstract A trinuclear Zinc(II) complex, [Zn3 L 2(μ-O2CCH3)2(H2O)2]·H2O·2CH3OH (1) of a (N,O)-donor Schiff base ligand has been synthesized and structurally characterized. The Zn(II) complex interacts significantly with CT-DNA and spectroscopic and viscosity investigations revealed an intercalative binding mode of 1 with DNA. The biological activity of the zinc(II) complex against different bacterial and fungal organisms is very promising. Indian Academy of Sciences, 2013 Zinc(II) nationallicence Schiff base nationallicence DNA binding study nationallicence antimicrobial investigation nationallicence BISWAS BHASKAR Department of Chemistry, Raghunathpur College, 723133, Purulia, India aut KOLE NIRANJAN Department of Chemistry, Raghunathpur College, 723133, Purulia, India aut PATRA MOUMITA Department of Physics, Raghunathpur College, 723133, Purulia, India aut DUTTA SHAMPA Department of Environmental Science, The University of Burdwan, 713 104, Burdwan, India aut GANGULY MOUSUMI Department of Environmental Science, The University of Burdwan, 713 104, Burdwan, India aut Journal of Chemical Sciences Springer India 125/6(2013-11-01), 1445-1453 0974-3626 125:6<1445 2013 125 12039 https://doi.org/10.1007/s12039-013-0528-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12039-013-0528-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- BISWAS BHASKAR Department of Chemistry, Raghunathpur College, 723133, Purulia, India aut NATIONALLICENCE 700 1- KOLE NIRANJAN Department of Chemistry, Raghunathpur College, 723133, Purulia, India aut NATIONALLICENCE 700 1- PATRA MOUMITA Department of Physics, Raghunathpur College, 723133, Purulia, India aut NATIONALLICENCE 700 1- DUTTA SHAMPA Department of Environmental Science, The University of Burdwan, 713 104, Burdwan, India aut NATIONALLICENCE 700 1- GANGULY MOUSUMI Department of Environmental Science, The University of Burdwan, 713 104, Burdwan, India aut NATIONALLICENCE 773 0- Journal of Chemical Sciences Springer India 125/6(2013-11-01), 1445-1453 0974-3626 125:6<1445 2013 125 12039 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer