naa a22 4500 510733735 CHVBK 20180411083002.0 cr unu---uuuuu 180411e20131101xx s 000 0 eng 10.1007/s12039-013-0509-4 doi (NATIONALLICENCE)springer-10.1007/s12039-013-0509-4 Facile green synthesis and potent antimicrobial efficacy of β -aminoheteronapthol via tailored Betti's protocol and their bis -aryl hydrazone click products [Elektronische Daten] [K KHANDARKAR, M SHANTI, M AHMED, J MESHRAM] A series of novel Mannich base and their hydrazone derivatives were synthesized by highly resourceful, chic, simple and green technique with exceptionally facile reaction conditions of one-pot, three component reaction with an array of biologically and pharmaceutically active novel heterocycles. The protocol offers a valuable alternative to known methods and will find applications in the field of green synthesis and antimicrobial study against pathogenic microbes, supporting the development of bioinformatical database of novel and derelict heterocycles. These data indicate their potential to become antifungal agents. The novel products were established by elemental, IR, mass spectroscopic and NMR analysis. The environmental advantages of the method include short reaction time, excellent yield, easy work-up, absence of extraction and chromatographic purification steps. Graphical Abstract We present a zeolite catalysed highly ingenious, facile, rapid and green one pot condensation of carbonyl compound, amine and heteronapthol via tailored Betti's protocol. The Betti's products viz. β-aminoheteronapthols, solubilised in minimum ethanol, were click condensed with hydrazine and carbonyl compound to give Betti's hydrazone derivative. Indian Academy of Sciences, 2013 Green synthesis nationallicence zeolite catalyst nationallicence click reaction nationallicence antimicrobial efficacy nationallicence KHANDARKAR K. Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, 440 033, Nagpur, India aut SHANTI M. Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, 440 033, Nagpur, India aut AHMED M. Department of Chemistry, Government Polytechnic Sakoli, 441 802, Bhandara, India aut MESHRAM J. Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, 440 033, Nagpur, India aut Journal of Chemical Sciences Springer India 125/6(2013-11-01), 1573-1594 0974-3626 125:6<1573 2013 125 12039 https://doi.org/10.1007/s12039-013-0509-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12039-013-0509-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- KHANDARKAR K. Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, 440 033, Nagpur, India aut NATIONALLICENCE 700 1- SHANTI M. Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, 440 033, Nagpur, India aut NATIONALLICENCE 700 1- AHMED M. Department of Chemistry, Government Polytechnic Sakoli, 441 802, Bhandara, India aut NATIONALLICENCE 700 1- MESHRAM J. Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, 440 033, Nagpur, India aut NATIONALLICENCE 773 0- Journal of Chemical Sciences Springer India 125/6(2013-11-01), 1573-1594 0974-3626 125:6<1573 2013 125 12039 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer