naa a22 4500 510733913 CHVBK 20180411083002.0 cr unu---uuuuu 180411e20130501xx s 000 0 eng 10.1007/s12039-013-0418-6 doi (NATIONALLICENCE)springer-10.1007/s12039-013-0418-6 Asymmetric synthesis of $\boldsymbol{\gamma}$ -aminophosphonates: The bio-isosteric analogs of $\boldsymbol{\gamma}$ -aminobutyric acid [Elektronische Daten] [KALISANKAR BERA, DWAYAJA NADKARNI, IRISHI NAMBOOTHIRI] The properties of aminophosphonates as transition state analogs of amino acids, and as antibacterial, antifungal and antiHIV agents attracted considerable attention in recent years. Although many reviews appeared in the literature covering α- and β-aminophosphonates, γ-aminophosphonates did not receive sufficient attention despite the fact that parent γ-aminophosphonic acid and its derivatives are bio-isosteric analogs of GABA (γ-amino butyric acid). This review provides a critical summary of the significance of γ-aminophosphonates and various approaches to their synthesis, with particular emphasis to asymmetric versions. Graphical Abstract The properties of aminophosphonates as transition state analogs of amino acids, and as anti-bacterial, antifungal and antiHIV agents attracted considerable attention. γ-Aminophosphonic acid in particular is a bio-isosteric analog of GABA (γ-aminobutyric acid). Indian Academy of Sciences, 2013 γ -Aminophosphonic acid nationallicence γ -aminobutyric acid nationallicence isosteric analogs nationallicence BERA KALISANKAR Department of Chemistry, Indian Institute of Technology Bombay, 400 076, Mumbai, India aut NADKARNI DWAYAJA Department of Chemistry, Indian Institute of Technology Bombay, 400 076, Mumbai, India aut NAMBOOTHIRI IRISHI Department of Chemistry, Indian Institute of Technology Bombay, 400 076, Mumbai, India aut Journal of Chemical Sciences Springer-Verlag 125/3(2013-05-01), 443-465 0974-3626 125:3<443 2013 125 12039 https://doi.org/10.1007/s12039-013-0418-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12039-013-0418-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- BERA KALISANKAR Department of Chemistry, Indian Institute of Technology Bombay, 400 076, Mumbai, India aut NATIONALLICENCE 700 1- NADKARNI DWAYAJA Department of Chemistry, Indian Institute of Technology Bombay, 400 076, Mumbai, India aut NATIONALLICENCE 700 1- NAMBOOTHIRI IRISHI Department of Chemistry, Indian Institute of Technology Bombay, 400 076, Mumbai, India aut NATIONALLICENCE 773 0- Journal of Chemical Sciences Springer-Verlag 125/3(2013-05-01), 443-465 0974-3626 125:3<443 2013 125 12039 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer