naa a22 4500 510733921 CHVBK 20180411083002.0 cr unu---uuuuu 180411e20130501xx s 000 0 eng 10.1007/s12039-013-0421-y doi (NATIONALLICENCE)springer-10.1007/s12039-013-0421-y Synthesis of 2-amino-4 H -chromene derivatives under microwave irradiation and their antimicrobial activity [Elektronische Daten] [NIRAV SHAH, NIMESH SHAH, MANISH PATEL, RANJAN PATEL] Libraries of 2-amino-4H-chromenes, were efficiently synthesized via one-pot, three-component reactions of 5-chloro-3-methyl-1-aryl-4,5-dihydro-1H-pyrazole-4-carbaldehyde (1a-c), 2-naphthols (2a-f) and malononitrile in the presence of catalytic amount of ammonium acetate under microwave irradiation. The protocol offers rapid synthesis of structurally diverse 2-amino-4H-chromenes for biological screening. All the synthesized compounds were evaluated for their antimicrobial activity, and several compounds exhibited moderate to potent antimicrobial activity. Graphical Abstract Libraries of 2-amino-4H-chromenes were efficiently synthesized via one-pot, three-component reactions of 5-chloro-3-methyl-1-aryl-4,5-dihydro-1H-pyrazole- 4-carbaldehyde (1a-c), 2-naphthols (2a-f) and malononitrile in the presence of catalytic amount of ammonium acetate under microwave irradiation. The compounds were evaluated for their antimicrobial activity, and several compounds exhibited moderate to potent antimicrobial activity. Indian Academy of Sciences, 2013 Multicomponent reactions (MCRs) nationallicence pyrazole nationallicence naphthols nationallicence SHAH NIRAV Department of Chemistry, Sardar Patel University, 388 120, Vallabh Vidyanagar, India aut SHAH NIMESH Department of Chemistry, Sardar Patel University, 388 120, Vallabh Vidyanagar, India aut PATEL MANISH Department of Chemistry, Sardar Patel University, 388 120, Vallabh Vidyanagar, India aut PATEL RANJAN Department of Chemistry, Sardar Patel University, 388 120, Vallabh Vidyanagar, India aut Journal of Chemical Sciences Springer-Verlag 125/3(2013-05-01), 525-530 0974-3626 125:3<525 2013 125 12039 https://doi.org/10.1007/s12039-013-0421-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12039-013-0421-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- SHAH NIRAV Department of Chemistry, Sardar Patel University, 388 120, Vallabh Vidyanagar, India aut NATIONALLICENCE 700 1- SHAH NIMESH Department of Chemistry, Sardar Patel University, 388 120, Vallabh Vidyanagar, India aut NATIONALLICENCE 700 1- PATEL MANISH Department of Chemistry, Sardar Patel University, 388 120, Vallabh Vidyanagar, India aut NATIONALLICENCE 700 1- PATEL RANJAN Department of Chemistry, Sardar Patel University, 388 120, Vallabh Vidyanagar, India aut NATIONALLICENCE 773 0- Journal of Chemical Sciences Springer-Verlag 125/3(2013-05-01), 525-530 0974-3626 125:3<525 2013 125 12039 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer