naa a22 4500 510733999 CHVBK 20180411083003.0 cr unu---uuuuu 180411e20130501xx s 000 0 eng 10.1007/s12039-013-0395-9 doi (NATIONALLICENCE)springer-10.1007/s12039-013-0395-9 New and rapid access to synthesis of novel polysubstituted imidazoles using antimony trichloride and stannous chloride dihydrate as effective and reusable catalysts [Elektronische Daten] [LEYLA POORALI, BAHADOR KARAMI, KHALIL ESKANDARI, MAHBOOBEH AZIZI] In this work, new, efficient and environmentally adapted synthesis of polysubstituted imidazoles in one-pot is repoted. The multicomponent reaction of various aldehydes, benzil, aliphatic and aromatic primary amines and ammonium acetate under solvent-free condition is explained. The highly efficient role of antimony trichloride and stannous chloride dihydrate as catalyst in this synthesis was shown and their effects on the reaction process were studied. By this advantage, several polysubstituted imidazoles as pharmaceutical important molecules can be prepared in high yield and high purity. This method is a very easy and rapid for the synthesis of imidazole derivatives. Graphical Abstract We report here a simple, rapid and one-pot procedure for the synthesis of tri and tetra-substituted imidazoles by the use of antimony trichloride and stannous chloride dihydrate with high yields and short reaction times under solvent-free conditions. Indian Academy of Sciences, 2013 Benzil nationallicence polysubstituted imidazoles nationallicence aldehydes nationallicence amines nationallicence heterogeneous catalyst nationallicence POORALI LEYLA Department of Chemistry, Gachsaran Branch, Islamic Azad University, 75817-75785, Gachsaran, Iran aut KARAMI BAHADOR Department of Chemistry, Yasouj University, P.O. Box 353, 75918-74831, Yasouj, Iran aut ESKANDARI KHALIL Department of Chemistry, Yasouj University, P.O. Box 353, 75918-74831, Yasouj, Iran aut AZIZI MAHBOOBEH Department of Chemistry, Gachsaran Branch, Islamic Azad University, 75817-75785, Gachsaran, Iran aut Journal of Chemical Sciences Springer-Verlag 125/3(2013-05-01), 591-599 0974-3626 125:3<591 2013 125 12039 https://doi.org/10.1007/s12039-013-0395-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12039-013-0395-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- POORALI LEYLA Department of Chemistry, Gachsaran Branch, Islamic Azad University, 75817-75785, Gachsaran, Iran aut NATIONALLICENCE 700 1- KARAMI BAHADOR Department of Chemistry, Yasouj University, P.O. Box 353, 75918-74831, Yasouj, Iran aut NATIONALLICENCE 700 1- ESKANDARI KHALIL Department of Chemistry, Yasouj University, P.O. Box 353, 75918-74831, Yasouj, Iran aut NATIONALLICENCE 700 1- AZIZI MAHBOOBEH Department of Chemistry, Gachsaran Branch, Islamic Azad University, 75817-75785, Gachsaran, Iran aut NATIONALLICENCE 773 0- Journal of Chemical Sciences Springer-Verlag 125/3(2013-05-01), 591-599 0974-3626 125:3<591 2013 125 12039 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer