naa a22 4500 510734111 CHVBK 20180411083003.0 cr unu---uuuuu 180411e20130501xx s 000 0 eng 10.1007/s12039-013-0420-z doi (NATIONALLICENCE)springer-10.1007/s12039-013-0420-z Synthesis of new series of 3-hydroxy/acetoxy-2-phenyl-4 H -chromen-4-ones and their biological importance [Elektronische Daten] [MANGESH GHARPURE, RATIRAM CHOUDHARY, VISHWAS INGLE, HARJEET JUNEJA] 3-Hydroxy-2-aryl/heteroaryl-4H-chromones 4(a-n) were synthesized from appropriate chalcones 3(a-n) and acetylated to afford the corresponding acetoxy derivatives 5(a-n). All compounds were evaluated for antimicrobial activity against Staphylococus aureus, Bacillus subtillis, Escherichia coli and Pseudomonas aeruginosa as well as fungi e.g., Candida albicans and Aspergius niger. Inhibition caused by hydroxy flavones was relatively low, whereas that of their acetoxy ester analogues was substantially high. Structure of 6-chloro-2-(furan-2-yl)-4-oxo-4H-chromen-3-yl acetate (5j) was also supported by means of single crystal X-ray diffraction. Graphical Abstract An effective microwave-assisted synthesis of 3-acetoxy-2-aryl/heteroaryl-4Hchromones 5a-n has been achieved through a series of reactions starting from phenols. These compounds have been screened against gram (+) ve and (-) ve bacteria. The acetoxy flavones were biologically more active than the corresponding hydroxyflavones. Indian Academy of Sciences, 2013 Chalcones nationallicence flavones nationallicence acetoxy ester nationallicence microwave irradiation nationallicence antimicrobial nationallicence X-ray crystal structure nationallicence GHARPURE MANGESH Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, 440 033, Nagpur, India aut CHOUDHARY RATIRAM Department of Chemistry, Seth Kesarimal Porwal College, 441 002, Kamptee, India aut INGLE VISHWAS Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, 440 033, Nagpur, India aut JUNEJA HARJEET Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, 440 033, Nagpur, India aut Journal of Chemical Sciences Springer-Verlag 125/3(2013-05-01), 575-582 0974-3626 125:3<575 2013 125 12039 https://doi.org/10.1007/s12039-013-0420-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12039-013-0420-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- GHARPURE MANGESH Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, 440 033, Nagpur, India aut NATIONALLICENCE 700 1- CHOUDHARY RATIRAM Department of Chemistry, Seth Kesarimal Porwal College, 441 002, Kamptee, India aut NATIONALLICENCE 700 1- INGLE VISHWAS Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, 440 033, Nagpur, India aut NATIONALLICENCE 700 1- JUNEJA HARJEET Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, 440 033, Nagpur, India aut NATIONALLICENCE 773 0- Journal of Chemical Sciences Springer-Verlag 125/3(2013-05-01), 575-582 0974-3626 125:3<575 2013 125 12039 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer