naa a22 4500 510734197 CHVBK 20180411083003.0 cr unu---uuuuu 180411e20130501xx s 000 0 eng 10.1007/s12039-013-0405-y doi (NATIONALLICENCE)springer-10.1007/s12039-013-0405-y SUBRAMANIAPILLAI SELVA School of Chemical and Biotechnology, SASTRA University, 613 401, Thanjavur, India aut Mannich reaction: A versatile and convenient approach to bioactive skeletons [Elektronische Daten] [SELVA SUBRAMANIAPILLAI] This review gives an insight into the recent applications of Mannich reaction and its variants in the construction of bioactive molecules. Emphasis is given to the Mannich reaction that provides bioactive molecules and/or modifies the property of an existing bioactive molecule. The role of Mannich reaction in the construction of antimalarial, antitumour, antimicrobial, antitubercular, antiinflammatory and anticonvulsant molecules and also the significance of aminoalkyl Mannich side chain on the biological property of molecules is discussed here. Graphical Abstract Mannich reaction plays a seminal role in the sysnthesis of numerous bioactive molecules. This review potrays applications of Mannich reaction and its variants in the construction of bioactive molecules and the role of aminoalkyl Mannich side chain on the property of bioactive/therapeutic molecules. Indian Academy of Sciences, 2013 Mannich reaction nationallicence Mannich bases nationallicence bioactive molecules nationallicence antimalarial nationallicence antitumour nationallicence antitubercular nationallicence Journal of Chemical Sciences Springer-Verlag 125/3(2013-05-01), 467-482 0974-3626 125:3<467 2013 125 12039 https://doi.org/10.1007/s12039-013-0405-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12039-013-0405-y text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- SUBRAMANIAPILLAI SELVA School of Chemical and Biotechnology, SASTRA University, 613 401, Thanjavur, India aut NATIONALLICENCE 773 0- Journal of Chemical Sciences Springer-Verlag 125/3(2013-05-01), 467-482 0974-3626 125:3<467 2013 125 12039 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer