naa a22 4500 510734308 CHVBK 20180411083004.0 cr unu---uuuuu 180411e20130701xx s 000 0 eng 10.1007/s12039-013-0459-x doi (NATIONALLICENCE)springer-10.1007/s12039-013-0459-x Brønsted acidic ionic liquid catalysis: An efficient and eco-friendly synthesis of novel fused pyrano pyrimidinones and their antimicrobial activity [Elektronische Daten] [JANARDHAN BANOTHU, RAJITHA GALI, RAVIBABU VELPULA, RAJITHA BAVANTULA] A series of novel fused pyrano pyrimidinones were synthesized by the condensation of 2-amino-4-aryl-4H-benzo[h]chromene-3-carbonitriles with 2-oxo-2H-chromene-3-carboxylic acid under neat conditions employing an efficient, eco-friendly and reusable Brønsted acidic ionic liquid, (4-sulfobutyl)tris(4-sulfophenyl)phosphonium hydrogen sulphate as catalyst. All the synthesized compounds were characterized by their analytical and spectroscopic data and they were screened for in vitro antibacterial activity against Bacillus subtilis, Staphylococcus aureus and Staphylococcus epidermidis as Gram- positive, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumonia as Gram-negative bacterial strains and antifungal activity against Aspergillus flavus, Saccharomyces cerevisiae, Candida rugosa and Candida albicans. Compounds 2c and 2d have shown good antibacterial activity against Escherichia coli while 2g has shown marked antifungal activity against Candida rugosa. Graphical Abstract Pyrano pyrimidinones were synthesized by the condensation of 2-amino-4-aryl-4H-benzo[h]chromene-3-carbonitriles with 2-oxo-2H-chromene-3-carboxylic acid in the presence of Brønsted acidic ionic liquid, (4-sulphobutyl)tris(4-sulphophenyl)phosphonium hydrogen sulphate as catalyst. All the synthesized compounds were screened for in vitro antimicrobial activity. Indian Academy of Sciences, 2013 Antibacterial activity nationallicence antifungal activity nationallicence Brønsted acidic ionic liquid nationallicence fused pyrano pyrimidinones nationallicence neat conditions nationallicence BANOTHU JANARDHAN Department of Chemistry, National Institute of Technology, 506 004, Warangal, India aut GALI RAJITHA Department of Chemistry, National Institute of Technology, 506 004, Warangal, India aut VELPULA RAVIBABU Department of Chemistry, National Institute of Technology, 506 004, Warangal, India aut BAVANTULA RAJITHA Department of Chemistry, National Institute of Technology, 506 004, Warangal, India aut Journal of Chemical Sciences Springer India 125/4(2013-07-01), 843-849 0974-3626 125:4<843 2013 125 12039 https://doi.org/10.1007/s12039-013-0459-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12039-013-0459-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- BANOTHU JANARDHAN Department of Chemistry, National Institute of Technology, 506 004, Warangal, India aut NATIONALLICENCE 700 1- GALI RAJITHA Department of Chemistry, National Institute of Technology, 506 004, Warangal, India aut NATIONALLICENCE 700 1- VELPULA RAVIBABU Department of Chemistry, National Institute of Technology, 506 004, Warangal, India aut NATIONALLICENCE 700 1- BAVANTULA RAJITHA Department of Chemistry, National Institute of Technology, 506 004, Warangal, India aut NATIONALLICENCE 773 0- Journal of Chemical Sciences Springer India 125/4(2013-07-01), 843-849 0974-3626 125:4<843 2013 125 12039 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer