naa a22 4500 510734367 CHVBK 20180411083004.0 cr unu---uuuuu 180411e20130701xx s 000 0 eng 10.1007/s12039-013-0426-6 doi (NATIONALLICENCE)springer-10.1007/s12039-013-0426-6 A new one-pot synthesis of 1,2,4-oxadiazoles from aryl nitriles, hydroxylamine and crotonoyl chloride [Elektronische Daten] [MASOUMEH ZAKERI, MAJID HERAVI, EBRAHIM ABOUZARI-LOTF] The reaction of aryl nitriles with hydroxylamine using acetic acid as a catalyst followed by subsequent addition of crotonoyl chloride to the intermediate amidoxime represents a straightforward one-pot access to new 1,2,4-oxadiazole synthesis under mild conditions. The course of the reaction was found to be high yielding and all new compounds were well characterized by nuclear magnetic resonance (NMR), mass spectrometry (MS) and elemental analysis. Graphical Abstract The reaction of aryl nitriles with hydroxylamine using acetic acid as a catalyst followed by subsequent addition of crotonoyl chloride to the intermediate amidoxime represents a straightforward one-pot access to new 1,2,4-oxadiazole synthesis under mild conditions. Indian Academy of Sciences, 2013 1,2,4-Oxadiazole nationallicence crotonoyl chloride nationallicence amidoxime nationallicence hydroxylamine nationallicence ZAKERI MASOUMEH Young Researchers and Elites Club, North Tehran Branch, Islamic Azad University, 15742, Tehran, Iran aut HERAVI MAJID Department of Chemistry, School of Sciences, Alzahra University, 1993891176, Tehran, Vanak, Iran aut ABOUZARI-LOTF EBRAHIM Institute of Hydrogen Economy, Energy Research Alliance, International Campus, Universiti Teknologi Malaysia, 54100, Kuala Lumpur, Malaysia aut Journal of Chemical Sciences Springer India 125/4(2013-07-01), 731-735 0974-3626 125:4<731 2013 125 12039 https://doi.org/10.1007/s12039-013-0426-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12039-013-0426-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- ZAKERI MASOUMEH Young Researchers and Elites Club, North Tehran Branch, Islamic Azad University, 15742, Tehran, Iran aut NATIONALLICENCE 700 1- HERAVI MAJID Department of Chemistry, School of Sciences, Alzahra University, 1993891176, Tehran, Vanak, Iran aut NATIONALLICENCE 700 1- ABOUZARI-LOTF EBRAHIM Institute of Hydrogen Economy, Energy Research Alliance, International Campus, Universiti Teknologi Malaysia, 54100, Kuala Lumpur, Malaysia aut NATIONALLICENCE 773 0- Journal of Chemical Sciences Springer India 125/4(2013-07-01), 731-735 0974-3626 125:4<731 2013 125 12039 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer