naa a22 4500 510734626 CHVBK 20180411083005.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s12039-013-0455-1 doi (NATIONALLICENCE)springer-10.1007/s12039-013-0455-1 Kinetics and mechanism of interaction of some bioactive ligands with cis -diaqua( cis -1,2-diaminocyclohexane)platinum(II) in aqueous medium [Elektronische Daten] [P KARMAKAR, S RAY, S MALLICK, B BERA, A MANDAL, S MONDAL, A GHOSH] The substitution reaction of cis-[Pt(cis-dach)(H2O)2]2 +  (where ‘dach' is cis-1,2-diaminocyclohexane) with 2-thiouracil (S, N), 1,2-cyclohexanedionedioxime (N, N) and acetylacetone (O, O) were studied in aqueous solution in 0.10M NaClO4 under pseudo-first order conditions as a functions of concentration, pH and temperature using UV-Vis spectrophotometry. The substitution reaction proceeds via rapid outer sphere association complex formation, followed by two slow consecutive steps. The first of these involves ligand-assisted deaquation, while second involves chelation as the second aqua ligand is displaced. The association equilibrium constant (KE) for the outer sphere complex formation has been evaluated together with rate constants for the two subsequent steps. The rate constants increase with increasing ligand concentration and the evaluated activation parameters for all reactions suggest an associative substitution mechanism for both the aqua ligand substitution processes. The product of the reaction has been characterized by IR, NMR and ESI-MS spectral analysis; which throws more light on the mechanistic behaviour of platinum(II) antitumour complexes. Graphical Abstract The interaction of cis-[Pt(cis-dach)(H2O)2]2 +  (where ‘dach' is cis-1,2- diaminocyclohexane) with 2-thiouracil (S, N), 1,2-cyclohexanedionedioxime (N, N) and acetylacetone (O, O) studied in aqueous solution; the products have been characterized by IR, NMR and ESI-MS analysis. Indian Academy of Sciences, 2013 Platinum(II) nationallicence diaminocyclohexane nationallicence kinetics nationallicence bioactivity nationallicence KARMAKAR P. Department of Chemistry, The University of Burdwan, 713 104, Burdwan, India aut RAY S. Department of Chemistry, The University of Burdwan, 713 104, Burdwan, India aut MALLICK S. Department of Chemistry, The University of Burdwan, 713 104, Burdwan, India aut BERA B. Department of Chemistry, The University of Burdwan, 713 104, Burdwan, India aut MANDAL A. Department of Chemistry, The University of Burdwan, 713 104, Burdwan, India aut MONDAL S. Department of Chemistry, The University of Burdwan, 713 104, Burdwan, India aut GHOSH A. Department of Chemistry, The University of Burdwan, 713 104, Burdwan, India aut Journal of Chemical Sciences Springer India 125/5(2013-09-01), 1133-1143 0974-3626 125:5<1133 2013 125 12039 https://doi.org/10.1007/s12039-013-0455-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12039-013-0455-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- KARMAKAR P. Department of Chemistry, The University of Burdwan, 713 104, Burdwan, India aut NATIONALLICENCE 700 1- RAY S. Department of Chemistry, The University of Burdwan, 713 104, Burdwan, India aut NATIONALLICENCE 700 1- MALLICK S. Department of Chemistry, The University of Burdwan, 713 104, Burdwan, India aut NATIONALLICENCE 700 1- BERA B. Department of Chemistry, The University of Burdwan, 713 104, Burdwan, India aut NATIONALLICENCE 700 1- MANDAL A. Department of Chemistry, The University of Burdwan, 713 104, Burdwan, India aut NATIONALLICENCE 700 1- MONDAL S. Department of Chemistry, The University of Burdwan, 713 104, Burdwan, India aut NATIONALLICENCE 700 1- GHOSH A. Department of Chemistry, The University of Burdwan, 713 104, Burdwan, India aut NATIONALLICENCE 773 0- Journal of Chemical Sciences Springer India 125/5(2013-09-01), 1133-1143 0974-3626 125:5<1133 2013 125 12039 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer