naa a22 4500 510734642 CHVBK 20180411083005.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s12039-013-0468-9 doi (NATIONALLICENCE)springer-10.1007/s12039-013-0468-9 An efficient synthesis of 3′-indolyl substituted pyrido[1,2- a ]benzimidazoles as potential antimicrobial and antioxidant agents [Elektronische Daten] [HARSHAD KATHROTIYA, MANISH PATEL] A new class of indole-based pyrido[1,2-a]benzimidazole derivatives 4a-r have been synthesized by one-pot cyclocondensation reaction of 2-phenyl-1H-indole-3-carboxaldehyde 1a-i, malononitrile 2 and 2-cyanomethylbenzimidazole 3a-b in the presence of catalytic amount of NaOH. In vitro antimicrobial activity of the synthesized compounds were investigated against a representative panel of pathogenic strains specifically three Gram-positive bacteria (Streptococcus pneumoniae, Clostridium tetani, Bacillus subtilis), three Gram-negative bacteria (Salmonella typhi, Vibrio cholerae, Escherichia coli) and two fungi (Aspergillus fumigatus, Candida albicans) using broth microdilution MIC (minimum inhibitory concentration) method. In vitro antioxidant activity was evaluated by ferric-reducing antioxidant power (FRAP) assay method. Compounds 4c, 4e, 4l and 4q have been found to be most efficient antimicrobial members while compounds 4h and 4p possess better ferric reducing antioxidant power. Graphical Abstract A series of pyrido[1,2-a]benzimidazole derivatives 4a-r have been synthesized. Antimicrobial activity against a representative panel of pathogenic strains and antioxidant activity were carried out. Compounds 4c, 4e, 4l and 4q emerged as most efficient antimicrobial members while compounds 4h and 4p showed better antioxidant power. Indian Academy of Sciences, 2013 Indole nationallicence pyrido[1,2- a ]benzimidazoles nationallicence multicomponent reaction nationallicence antimicrobial activity nationallicence FRAP assay nationallicence KATHROTIYA HARSHAD Department of Chemistry, Sardar Patel University, 388120, Vallabh Vidyanagar, India aut PATEL MANISH Department of Chemistry, Sardar Patel University, 388120, Vallabh Vidyanagar, India aut Journal of Chemical Sciences Springer India 125/5(2013-09-01), 993-1001 0974-3626 125:5<993 2013 125 12039 https://doi.org/10.1007/s12039-013-0468-9 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12039-013-0468-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- KATHROTIYA HARSHAD Department of Chemistry, Sardar Patel University, 388120, Vallabh Vidyanagar, India aut NATIONALLICENCE 700 1- PATEL MANISH Department of Chemistry, Sardar Patel University, 388120, Vallabh Vidyanagar, India aut NATIONALLICENCE 773 0- Journal of Chemical Sciences Springer India 125/5(2013-09-01), 993-1001 0974-3626 125:5<993 2013 125 12039 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer