naa a22 4500 510734693 CHVBK 20180411083005.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s12039-013-0473-z doi (NATIONALLICENCE)springer-10.1007/s12039-013-0473-z DNA binding and cleavage activity by a mononuclear iron(II)Schiff base complex: Synthesis and structural characterization [Elektronische Daten] [ABHIJIT PAL, BHASKAR BISWAS, MERRY MITRA, SUBRAMANIYAM RAJALAKSHMI, CHANDRA PUROHIT, SOUMITRA HAZRA, GOPINATHA KUMAR, BALACHANDRAN NAIR, RAJARSHI GHOSH] Synthesis and characterization of a mononuclear Fe(II) compound [Fe(L)](ClO4)2 (1) [L = N-(1-pyridin-2-yl-phenylidene)-N′-[2-({2-[(1-pyridin-2-ylphenylidene)amino]ethyl}amino)ethyl] ethane-1,2-diamine] (1) is reported. 1 crystallizes in P-1 space group with a = 11.9241(3) Å, b = 12.1994(3) Å and c= 13.0622(4) Å. The binding property of the complex with DNA has been investigated using absorption and emission studies, thermal melting, viscosity experiments and circular dichroism studies. The binding constant (K b) and the linear Stern-Volmer quenching constant (K sv) of the complex have been determined as 3.5 × 103 M − 1 and 2.73 × 104 M − 1, respectively. Spectroscopic and hydrodynamic investigations revealed intercalative mode of binding of 1 with DNA. 1 is also found to induce oxidative cleavage of the supercoiled pUC 18 DNA to its nicked circular form in a concentration dependent manner. Graphical Abstract Synthesis and X-ray structural characterization of a mononuclear Fe(II) compound [Fe(L)](ClO4)2 [L = neutral N-donor Schiff base] (1) are presented. Spectroscopic and hydrodynamic investigations revealed intercalative mode of binding of 1 with DNA. 1 is also found to induce concentration dependent oxidative cleavage of supercoiled DNA. 100% conversion of DNA from its supercoiled to nicked form is found with 1 in the presence of a small amount of oxidizing agent (1 μM H2O2). Indian Academy of Sciences, 2013 Iron(II) nationallicence Schiff base nationallicence X-ray structure nationallicence DNA binding nationallicence DNA cleavage nationallicence PAL ABHIJIT Department of Chemistry, The University of Burdwan, 713 104, Burdwan, India aut BISWAS BHASKAR Department of Chemistry, The University of Burdwan, 713 104, Burdwan, India aut MITRA MERRY Department of Chemistry, The University of Burdwan, 713 104, Burdwan, India aut RAJALAKSHMI SUBRAMANIYAM Chemical Laboratory, CSIR-Central Leather Research Institute, 600 020, Chennai, Adayar, India aut PUROHIT CHANDRA Department of Chemical Sciences, National Institute of Science Education and Research, 751 005, Bhubaneswar, India aut HAZRA SOUMITRA Biophysical Chemistry Laboratory, Chemistry Division, CSIR-Indian Institute of Chemical Biology, 700 032, Kolkata, India aut KUMAR GOPINATHA Biophysical Chemistry Laboratory, Chemistry Division, CSIR-Indian Institute of Chemical Biology, 700 032, Kolkata, India aut NAIR BALACHANDRAN Chemical Laboratory, CSIR-Central Leather Research Institute, 600 020, Chennai, Adayar, India aut GHOSH RAJARSHI Department of Chemistry, The University of Burdwan, 713 104, Burdwan, India aut Journal of Chemical Sciences Springer India 125/5(2013-09-01), 1161-1168 0974-3626 125:5<1161 2013 125 12039 https://doi.org/10.1007/s12039-013-0473-z text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12039-013-0473-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- PAL ABHIJIT Department of Chemistry, The University of Burdwan, 713 104, Burdwan, India aut NATIONALLICENCE 700 1- BISWAS BHASKAR Department of Chemistry, The University of Burdwan, 713 104, Burdwan, India aut NATIONALLICENCE 700 1- MITRA MERRY Department of Chemistry, The University of Burdwan, 713 104, Burdwan, India aut NATIONALLICENCE 700 1- RAJALAKSHMI SUBRAMANIYAM Chemical Laboratory, CSIR-Central Leather Research Institute, 600 020, Chennai, Adayar, India aut NATIONALLICENCE 700 1- PUROHIT CHANDRA Department of Chemical Sciences, National Institute of Science Education and Research, 751 005, Bhubaneswar, India aut NATIONALLICENCE 700 1- HAZRA SOUMITRA Biophysical Chemistry Laboratory, Chemistry Division, CSIR-Indian Institute of Chemical Biology, 700 032, Kolkata, India aut NATIONALLICENCE 700 1- KUMAR GOPINATHA Biophysical Chemistry Laboratory, Chemistry Division, CSIR-Indian Institute of Chemical Biology, 700 032, Kolkata, India aut NATIONALLICENCE 700 1- NAIR BALACHANDRAN Chemical Laboratory, CSIR-Central Leather Research Institute, 600 020, Chennai, Adayar, India aut NATIONALLICENCE 700 1- GHOSH RAJARSHI Department of Chemistry, The University of Burdwan, 713 104, Burdwan, India aut NATIONALLICENCE 773 0- Journal of Chemical Sciences Springer India 125/5(2013-09-01), 1161-1168 0974-3626 125:5<1161 2013 125 12039 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer