naa a22 4500 510734723 CHVBK 20180411083005.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s12039-013-0483-x doi (NATIONALLICENCE)springer-10.1007/s12039-013-0483-x Antiplasmodial and larvicidal compounds of Toddalia asiatica root bark [Elektronische Daten] [T NYAHANGA, J JONDIKO, L MANGURO, J ORWA] From the n-hexane, ethyl acetate and methanol extracts of Toddalia asiatica root bark were isolated eight compounds (1-8) which were identified on the basis of both spectroscopic and physical data as well as comparison with already published results. The crude extracts and isolated compounds showed moderate in vitro antiplasmodial activity against D6 (chloroquine-sensitive) and W2 (chloroquine-resistant) strains of Plasmodium falciparum. The extracts and isolates also exhibited larvicidal activities against Aedes aegypti and coumarins were identified as the active compounds. Graphical Abstract Chemical examination of Toddalia asiatica root bark resulted into the isolation of eight compounds which were evaluated for antiplasmodial and larvicidal activities. Toddaculatin (3) was the most active against chloroquine sensitive D6 strain of Plasmodium falciparum while toddanol (6) was found to be toxic against Aedes aegyti 2nd instar larvae. Indian Academy of Sciences, 2013 Toddalia asiatica nationallicence Rutaceae nationallicence coumarins nationallicence alkaloid nationallicence antiplasmodial nationallicence larvicidal activities nationallicence NYAHANGA T. Department of Chemistry, Maseno University, P. O. Box 333-40105, Maseno, Kenya aut JONDIKO J. Department of Chemistry, Maseno University, P. O. Box 333-40105, Maseno, Kenya aut MANGURO L. Department of Chemistry, Maseno University, P. O. Box 333-40105, Maseno, Kenya aut ORWA J. Kenya Medical Research Institute, Centre for Traditional Medicine and Drug Research, P. O. Box 54840-00200, Nairobi, Kenya aut Journal of Chemical Sciences Springer India 125/5(2013-09-01), 1115-1121 0974-3626 125:5<1115 2013 125 12039 https://doi.org/10.1007/s12039-013-0483-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12039-013-0483-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- NYAHANGA T. Department of Chemistry, Maseno University, P. O. Box 333-40105, Maseno, Kenya aut NATIONALLICENCE 700 1- JONDIKO J. Department of Chemistry, Maseno University, P. O. Box 333-40105, Maseno, Kenya aut NATIONALLICENCE 700 1- MANGURO L. Department of Chemistry, Maseno University, P. O. Box 333-40105, Maseno, Kenya aut NATIONALLICENCE 700 1- ORWA J. Kenya Medical Research Institute, Centre for Traditional Medicine and Drug Research, P. O. Box 54840-00200, Nairobi, Kenya aut NATIONALLICENCE 773 0- Journal of Chemical Sciences Springer India 125/5(2013-09-01), 1115-1121 0974-3626 125:5<1115 2013 125 12039 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer