naa a22 4500 510734731 CHVBK 20180411083005.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s12039-013-0493-8 doi (NATIONALLICENCE)springer-10.1007/s12039-013-0493-8 Ionic liquid-mediated three-component synthesis of fluorinated spiro-thiazine derivatives and their antimycobacterial and DNA cleavage activities [Elektronische Daten] [ANSHU DANDIA, RUBY SINGH, DEEPTI SAINI] A simple, green and catalyst-free novel protocol is developed for the synthesis of medicinally important spiro[indole-3,2′[1,3]-thiazine]-2,4′-dione and spiro[acenaphthylene-1,2′-[1,3]thiazine]dione libraries by the tandem reaction of readily available reagents in 1-butyl-3-methylimidazolium hexafluorophosphate [bmim][PF6]. The ionic liquid has been used as a solvent as well as catalyst for this reaction. This reaction proceeded smoothly in good to excellent yields and offered several other advantages including short reaction time, simple experimental workup procedure and no by-products. The synthesized compounds were subjected to antimycobacterial efficacy against Mycobacterium tuberculosis H37Rv strain and DNA cleavage activity. Graphical Abstract A highly practical and efficient preparation of spiro[indole-3,2′[1,3]-thiazine]-2,4′-dione and spiro[acenaphthylene-1,2′-[1,3]thiazine]dione derivatives was developed via an ionic liquid mediated and promoted multi-component reaction of indole-2,3-dione/acenaphthalene-1,2-dione, aniline and 3-mercaptopropionic acid. The synthesized compounds were subjected to antimycobacterial efficacy against M. tuberculosis H37Rv strain and DNA cleavage activity. Indian Academy of Sciences, 2013 Environmentally benign nationallicence spiro-thiazine derivative nationallicence tandem reaction nationallicence antimycobacterial activity nationallicence DNA scavenging activity nationallicence DANDIA ANSHU Department of Chemistry, University of Rajasthan, 302 004, Jaipur, India aut SINGH RUBY Department of Chemistry, University of Rajasthan, 302 004, Jaipur, India aut SAINI DEEPTI Department of Chemistry, University of Rajasthan, 302 004, Jaipur, India aut Journal of Chemical Sciences Springer India 125/5(2013-09-01), 1045-1053 0974-3626 125:5<1045 2013 125 12039 https://doi.org/10.1007/s12039-013-0493-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12039-013-0493-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- DANDIA ANSHU Department of Chemistry, University of Rajasthan, 302 004, Jaipur, India aut NATIONALLICENCE 700 1- SINGH RUBY Department of Chemistry, University of Rajasthan, 302 004, Jaipur, India aut NATIONALLICENCE 700 1- SAINI DEEPTI Department of Chemistry, University of Rajasthan, 302 004, Jaipur, India aut NATIONALLICENCE 773 0- Journal of Chemical Sciences Springer India 125/5(2013-09-01), 1045-1053 0974-3626 125:5<1045 2013 125 12039 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer