naa a22 4500 510734774 CHVBK 20180411083005.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s12039-013-0492-9 doi (NATIONALLICENCE)springer-10.1007/s12039-013-0492-9 Synthesis and evaluation of some novel precursors of oxazolidinone analogues of chloroquinoline for their antimicrobial and cytotoxic potential [Elektronische Daten] [KAVITA DEVI, KAVITA ASMAT, MEENAKSHI AGRAWAL, SWAPNIL SHARMA, JAYA DWIVEDI] Some 3-(3-(7-chloroquinolin-4-ylamino)propyl-2-imino-5-(4-chloro/nitro/methoxy benzylidene) oxazolidin-4-one 4(a-c) and 4-(3-(7-chloroquinolin-4-ylamino) propyl)-2(4-chloro/nitro/methoxy benzylidene)-1,6-diox-4,9 diazaspiro[4,4]nonane-3,8-dione 5(a-c) derivatives were synthesized using appropriate synthetic route. The newly prepared compounds 5a-c demonstrated inhibitory effects on the growth of a MCF7 (hormone-dependant breast carcinoma cell line), HT29 (colon carcinoma cell line on leukemia). The MCF7 cell line was found to be very susceptible towards compound 5a with IC50 values of 16 μg/ml. Similarly, the HT29 cell line was found to be moderately susceptible towards compounds 5a and 5c with IC 50 values of 32 and 49 μg/ml, respectively. Graphical Abstract A series of novel spiro oxazolidinone 5(a-c) was synthesized in multistep reactions. Newly synthesized compounds were characterized and screened for their in-vitro cytotoxic potential against MCF7 and HT29 cell lines. Indian Academy of Sciences, 2013 Synthesis nationallicence 4-7-dichloroquinoline nationallicence 1-3-diaminopropane nationallicence oxazolidinone nationallicence antimicrobial activity and cytotoxicity study nationallicence DEVI KAVITA Department of Chemistry, Banasthali University, 304 022, Banasthali, India aut ASMAT KAVITA Department of Chemistry, Banasthali University, 304 022, Banasthali, India aut AGRAWAL MEENAKSHI Department of Chemistry, Banasthali University, 304 022, Banasthali, India aut SHARMA SWAPNIL Department of Pharmacy, Banasthali University, 304 022, Banasthali, India aut DWIVEDI JAYA Department of Chemistry, Banasthali University, 304 022, Banasthali, India aut Journal of Chemical Sciences Springer India 125/5(2013-09-01), 1093-1101 0974-3626 125:5<1093 2013 125 12039 https://doi.org/10.1007/s12039-013-0492-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12039-013-0492-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- DEVI KAVITA Department of Chemistry, Banasthali University, 304 022, Banasthali, India aut NATIONALLICENCE 700 1- ASMAT KAVITA Department of Chemistry, Banasthali University, 304 022, Banasthali, India aut NATIONALLICENCE 700 1- AGRAWAL MEENAKSHI Department of Chemistry, Banasthali University, 304 022, Banasthali, India aut NATIONALLICENCE 700 1- SHARMA SWAPNIL Department of Pharmacy, Banasthali University, 304 022, Banasthali, India aut NATIONALLICENCE 700 1- DWIVEDI JAYA Department of Chemistry, Banasthali University, 304 022, Banasthali, India aut NATIONALLICENCE 773 0- Journal of Chemical Sciences Springer India 125/5(2013-09-01), 1093-1101 0974-3626 125:5<1093 2013 125 12039 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer