naa a22 4500 510734871 CHVBK 20180411083006.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s12039-013-0486-7 doi (NATIONALLICENCE)springer-10.1007/s12039-013-0486-7 Photo-induced antimicrobial and DNA cleavage studies of indoloquinolines and 1,8-naphtharidine [Elektronische Daten] [MALATHI MAHALINGAM, PALATHURAI MOHAN, KASIRAJAN GAYATHRI, RAMADOSS GOMATHI, PUSHPARAJA SUBHAPRIYA] Angular and linear isomers of indoloquinoline are synthesized from 4-hydroxyquinolin-2(1H)-one. The use of Vilsmeier-Haack reagent on N-phenylpropionamide yielded a new versatile method for the synthesis of 2-chloro-3-methylquinoline which is utilized as precursor in the synthesis of basic camptothecin core and quinoline fused with 1,8-naphthridine. The in vivo photoinduced antibacterial activity of all the synthesized compounds has been studied. The unique photo-bioactivity of 5H-indolo[3,2-c]quinolin-6(11H)-one is further studied under the photo-DNA cleavage analysis. Theoretical calculations for the synthesized compounds are performed to determine further credentials of the biological results. Graphical Abstract Angular and linear isomers of indoloquinoline were synthesized and the in vivo photo-induced antibacterial activities were studied. Theoretical calculations for the synthesized compounds were performed to explore structural-activity correlation. Indian Academy of Sciences, 2013 Vilsmeier-Haack reagent nationallicence indoloquinolines nationallicence photosensitizer nationallicence photoinduced antibacterial activity nationallicence photo-DNA binding nationallicence MAHALINGAM MALATHI Department of Chemistry, Bharathiar University, 641 046, Coimbatore, India aut MOHAN PALATHURAI Department of Chemistry, Bharathiar University, 641 046, Coimbatore, India aut GAYATHRI KASIRAJAN Department of Chemistry, Bharathiar University, 641 046, Coimbatore, India aut GOMATHI RAMADOSS Department of Chemistry, Bharathiar University, 641 046, Coimbatore, India aut SUBHAPRIYA PUSHPARAJA Department of Chemistry, Bannari Amman Institute of Technology, 638 401, Sathyamangalam, India aut Journal of Chemical Sciences Springer India 125/5(2013-09-01), 1015-1027 0974-3626 125:5<1015 2013 125 12039 https://doi.org/10.1007/s12039-013-0486-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12039-013-0486-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- MAHALINGAM MALATHI Department of Chemistry, Bharathiar University, 641 046, Coimbatore, India aut NATIONALLICENCE 700 1- MOHAN PALATHURAI Department of Chemistry, Bharathiar University, 641 046, Coimbatore, India aut NATIONALLICENCE 700 1- GAYATHRI KASIRAJAN Department of Chemistry, Bharathiar University, 641 046, Coimbatore, India aut NATIONALLICENCE 700 1- GOMATHI RAMADOSS Department of Chemistry, Bharathiar University, 641 046, Coimbatore, India aut NATIONALLICENCE 700 1- SUBHAPRIYA PUSHPARAJA Department of Chemistry, Bannari Amman Institute of Technology, 638 401, Sathyamangalam, India aut NATIONALLICENCE 773 0- Journal of Chemical Sciences Springer India 125/5(2013-09-01), 1015-1027 0974-3626 125:5<1015 2013 125 12039 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer