naa a22 4500 510734901 CHVBK 20180411083006.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s12039-013-0485-8 doi (NATIONALLICENCE)springer-10.1007/s12039-013-0485-8 Design, synthesis and cytotoxic activity of some novel compounds containing pyrazolo[3,4- d ]pyrimidines nucleus [Elektronische Daten] [MANAL KANDEEL, SAMEHA ROSHDY, EMAN ABDELALL, MOHAMED ABDELGAWAD, PHOEBE LAMIE] Novel pyrazolo[3,4-d]pyrimidines were designed and synthesized as antitumour agents against human breast cancer adenoma (MCF-7). Molecular modelling and pharmacological screening were performed against breast cancer cell line and also certain synthetic pathways were developed in order to introduce functionality onto C6 and N5 positions of pyrimidine moiety. Surprisingly, all the test compounds showed IC50 lower than that of the standard olomoucine I, especially compounds 4b, 8a, 10b, 11a and b, which showed IC50 between 0.009 and 0.004 $\upmu $ M. Graphical Abstract Compounds with substitution on 1, 5 and 6 sites of pyrazolo [3,4-d] pyrimidinones were synthesized to match the action of cyclin-dependent kinases (CDK) inhibitors. The newly synthesized compounds were evaluated in vitro for their anticancer activity. There was some sort of consistency between modelling study and results of anticancer screening. Indian Academy of Sciences, 2013 Pyrazolo[3,4- d ]pyrimidine derivatives nationallicence cytotoxic activity nationallicence MCF-7 nationallicence cyclin-dependent kinase inhibitors (CDKI) nationallicence KANDEEL MANAL Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Giza, Egypt aut ROSHDY SAMEHA Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Giza, Egypt aut ABDELALL EMAN Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni Suef University, Beni Suef, Egypt aut ABDELGAWAD MOHAMED Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni Suef University, Beni Suef, Egypt aut LAMIE PHOEBE Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni Suef University, Beni Suef, Egypt aut Journal of Chemical Sciences Springer India 125/5(2013-09-01), 1029-1043 0974-3626 125:5<1029 2013 125 12039 https://doi.org/10.1007/s12039-013-0485-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12039-013-0485-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- KANDEEL MANAL Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Giza, Egypt aut NATIONALLICENCE 700 1- ROSHDY SAMEHA Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Giza, Egypt aut NATIONALLICENCE 700 1- ABDELALL EMAN Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni Suef University, Beni Suef, Egypt aut NATIONALLICENCE 700 1- ABDELGAWAD MOHAMED Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni Suef University, Beni Suef, Egypt aut NATIONALLICENCE 700 1- LAMIE PHOEBE Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni Suef University, Beni Suef, Egypt aut NATIONALLICENCE 773 0- Journal of Chemical Sciences Springer India 125/5(2013-09-01), 1029-1043 0974-3626 125:5<1029 2013 125 12039 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer