naa a22 4500 51073491X CHVBK 20180411083006.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s12039-013-0444-4 doi (NATIONALLICENCE)springer-10.1007/s12039-013-0444-4 Electrochemical studies of ropinirole, an anti-Parkinson's disease drug [Elektronische Daten] [BILJANA NIGOVIĆ, SANDRA JURIĆ, ANA MORNAR, INES MALENICA] Graphical Abstract The electrochemical behaviour of ropinirole has been examined for the first time. The voltammetric response attributed to the oxidation of indol-2-one ring was used for electroanalytical measurements of drug molecule. The oxidation behaviour of a potent anti-Parkinson's disease drug ropinirole hydrochloride was investigated over a wide pH range in aqueous solution at glassy carbon electrode using cyclic and square-wave voltammetry. The oxidation of drug is a pH dependent irreversible process and occurs in two steps. The mechanism of the oxidation process has been discussed. Using the sharp oxidation response in 0.1M sulphuric acid at a potential of +1.27V attributed to the oxidation of indol-2-one ring in drug molecule, rapid electroanalytical methods for the determination of ropinirole by pulse voltammetric techniques were developed and validated. The proposed voltammetric methods were applied to direct quantification of ropinirole in film-coated tablets, with results in close agreement (at 95% confidence level) with those obtained using a comparative HPLC method. Indian Academy of Sciences, 2013 Ropinirole hydrochloride nationallicence electrochemical oxidation nationallicence voltammetry nationallicence glassy carbon electrode nationallicence pharmaceutical analysis nationallicence NIGOVIĆ BILJANA Faculty of Pharmacy and Biochemistry, University of Zagreb, A Kovacica 1, 10000, Zagreb, Croatia aut JURIĆ SANDRA Faculty of Pharmacy and Biochemistry, University of Zagreb, A Kovacica 1, 10000, Zagreb, Croatia aut MORNAR ANA Faculty of Pharmacy and Biochemistry, University of Zagreb, A Kovacica 1, 10000, Zagreb, Croatia aut MALENICA INES Faculty of Pharmacy and Biochemistry, University of Zagreb, A Kovacica 1, 10000, Zagreb, Croatia aut Journal of Chemical Sciences Springer India 125/5(2013-09-01), 1197-1205 0974-3626 125:5<1197 2013 125 12039 https://doi.org/10.1007/s12039-013-0444-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12039-013-0444-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- NIGOVIĆ BILJANA Faculty of Pharmacy and Biochemistry, University of Zagreb, A Kovacica 1, 10000, Zagreb, Croatia aut NATIONALLICENCE 700 1- JURIĆ SANDRA Faculty of Pharmacy and Biochemistry, University of Zagreb, A Kovacica 1, 10000, Zagreb, Croatia aut NATIONALLICENCE 700 1- MORNAR ANA Faculty of Pharmacy and Biochemistry, University of Zagreb, A Kovacica 1, 10000, Zagreb, Croatia aut NATIONALLICENCE 700 1- MALENICA INES Faculty of Pharmacy and Biochemistry, University of Zagreb, A Kovacica 1, 10000, Zagreb, Croatia aut NATIONALLICENCE 773 0- Journal of Chemical Sciences Springer India 125/5(2013-09-01), 1197-1205 0974-3626 125:5<1197 2013 125 12039 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer