naa a22 4500 510735002 CHVBK 20180411092754.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s12039-013-0371-4 doi (NATIONALLICENCE)springer-10.1007/s12039-013-0371-4 Synthesis, characterization and antimicrobial screening of hybrid molecules containing quinoline, pyrimidine and morpholine analogues [Elektronische Daten] [N DESAI, K RAJPARA, V JOSHI, H VAGHANI, H SATODIYA] In an attempt to find new bio-active molecules, a series of compounds N-(4-(2-chloroquinolin-3-yl)-6-(aryl)pyrimidin-2-yl)-2-morpholinoacetamides (5a-l) were synthesized by multistep reactions. Compounds were characterized by IR, NMR and mass spectra. Antimicrobial screening of title compounds (5a-l) was carried out against Gram-positive bacteria (Staphylococcus aureus, Streptococcus pyogenes), Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa) and fungi (Candida albicans, Aspergillus niger, Aspergillus clavatus) using serial broth dilution method. On the basis of statistical analysis, it is observed that these compounds gave significant co-relation. Newly synthesized compounds 5e, 5f, 5g, 5i and 5l showed significant potency against different microbial strains. Graphical Abstract A novel series of compounds N-(4-(2-chloroquinolin-3-yl)-6-(aryl)pyrimidin-2-yl)-2-morpholinoacetamides (5a-l) were synthesized by multi-step reactions. Newly synthesized compounds were characterized by various spectroscopic techniques and screened for in vitro antimicrobial activity. Indian Academy of Sciences, 2013 Quinoline nationallicence pyrimidine and morpholine nationallicence antibacterial activity nationallicence antifungal activity nationallicence MIC nationallicence DESAI N. Division of Medicinal Chemistry, Department of Chemistry (DST-FIST Sponsored Department), Mahatma Gandhi Campus, Maharaja Krishnakumarsinhji Bhavnagar University, 364 002, Bhavnagar, dnisheeth@rediffmail.com, India aut RAJPARA K. Division of Medicinal Chemistry, Department of Chemistry (DST-FIST Sponsored Department), Mahatma Gandhi Campus, Maharaja Krishnakumarsinhji Bhavnagar University, 364 002, Bhavnagar, dnisheeth@rediffmail.com, India aut JOSHI V. Division of Medicinal Chemistry, Department of Chemistry (DST-FIST Sponsored Department), Mahatma Gandhi Campus, Maharaja Krishnakumarsinhji Bhavnagar University, 364 002, Bhavnagar, dnisheeth@rediffmail.com, India aut VAGHANI H. Division of Medicinal Chemistry, Department of Chemistry (DST-FIST Sponsored Department), Mahatma Gandhi Campus, Maharaja Krishnakumarsinhji Bhavnagar University, 364 002, Bhavnagar, dnisheeth@rediffmail.com, India aut SATODIYA H. Division of Medicinal Chemistry, Department of Chemistry (DST-FIST Sponsored Department), Mahatma Gandhi Campus, Maharaja Krishnakumarsinhji Bhavnagar University, 364 002, Bhavnagar, dnisheeth@rediffmail.com, India aut Journal of Chemical Sciences Springer-Verlag 125/2(2013-03-01), 321-333 0974-3626 125:2<321 2013 125 12039 https://doi.org/10.1007/s12039-013-0371-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12039-013-0371-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- DESAI N. Division of Medicinal Chemistry, Department of Chemistry (DST-FIST Sponsored Department), Mahatma Gandhi Campus, Maharaja Krishnakumarsinhji Bhavnagar University, 364 002, Bhavnagar, dnisheeth@rediffmail.com, India aut NATIONALLICENCE 700 1- RAJPARA K. Division of Medicinal Chemistry, Department of Chemistry (DST-FIST Sponsored Department), Mahatma Gandhi Campus, Maharaja Krishnakumarsinhji Bhavnagar University, 364 002, Bhavnagar, dnisheeth@rediffmail.com, India aut NATIONALLICENCE 700 1- JOSHI V. Division of Medicinal Chemistry, Department of Chemistry (DST-FIST Sponsored Department), Mahatma Gandhi Campus, Maharaja Krishnakumarsinhji Bhavnagar University, 364 002, Bhavnagar, dnisheeth@rediffmail.com, India aut NATIONALLICENCE 700 1- VAGHANI H. Division of Medicinal Chemistry, Department of Chemistry (DST-FIST Sponsored Department), Mahatma Gandhi Campus, Maharaja Krishnakumarsinhji Bhavnagar University, 364 002, Bhavnagar, dnisheeth@rediffmail.com, India aut NATIONALLICENCE 700 1- SATODIYA H. Division of Medicinal Chemistry, Department of Chemistry (DST-FIST Sponsored Department), Mahatma Gandhi Campus, Maharaja Krishnakumarsinhji Bhavnagar University, 364 002, Bhavnagar, dnisheeth@rediffmail.com, India aut NATIONALLICENCE 773 0- Journal of Chemical Sciences Springer-Verlag 125/2(2013-03-01), 321-333 0974-3626 125:2<321 2013 125 12039 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 493330615 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer