naa a22 4500 510735010 CHVBK 20180411083006.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s12039-013-0382-1 doi (NATIONALLICENCE)springer-10.1007/s12039-013-0382-1 Carbon paste electrode incorporating multi-walled carbon nanotube/ferrocene as a sensor for the electroanalytical determination of N -acetyl- L -cysteine in the presence of tryptophan [Elektronische Daten] [JAHAN RAOOF, FERESHTEH CHEKIN, REZA OJANI, SAEIDEH BARARI] The preparation and electrochemical performance of the carbon nanotube paste electrode modified with ferrocene (FCMCNPE) was investigated for electrocatalytic behaviour toward oxidation of N-acetyl-L-cysteine (NAC) in the presence of tryptophan (Trp) using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The results showed an efficient electrocatalytic activity of FCMCNPE toward oxidation of NAC and Trp, as the electrooxidation of NAC and Trp together gave two well-defined anodic peaks, revealing the applicability of this modified electrode for simultaneous voltammetric detection of mentioned compounds in the same solution. The values of catalytic rate constant (k) and the apparent diffusion coefficient (Dapp) were also calculated using chronoamperometry. The DPV method was applied as a sensitive method for the quantitative detection of trace amounts of NAC and Trp. A linear dynamic range from 1.0 to 18.0 $\upmu $ M for NAC and 2.0 to 150.0 $\upmu $ M for Trp was obtained using DPV method in pH7.00 buffered solution and the detection limit (3σ) was determined as 0.49 $\upmu $ M and 0.54 $\upmu $ M for NAC and Trp, respectively. The proposed method was also applied for analysis of NAC tablet, investigating the applicability of the proposed voltammetric method for determination of NAC in real sample. Graphical Abstract A carbon nanotube paste electrode modified with ferrocene (FCMCNPE) was prepared and utilized for selective determination of N-acetyl-L-cysteine (NAC) in the presence of tryptophan (Trp). The modified electrode exhibited efficient electrocatalytic activity toward NAC oxidation. Indian Academy of Sciences, 2013 N -acetyl- L -cysteine nationallicence tryptophan nationallicence ferrocene nationallicence electrocatalysis nationallicence carbon nanotube paste electrode nationallicence RAOOF JAHAN Electroanalytical Chemistry Research Laboratory, Department of Analytical Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran aut CHEKIN FERESHTEH Department of Chemistry, Islamic Azad University, Ayatollah Amoli Branch, Amol, Iran aut OJANI REZA Electroanalytical Chemistry Research Laboratory, Department of Analytical Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran aut BARARI SAEIDEH Electroanalytical Chemistry Research Laboratory, Department of Analytical Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran aut Journal of Chemical Sciences Springer-Verlag 125/2(2013-03-01), 283-289 0974-3626 125:2<283 2013 125 12039 https://doi.org/10.1007/s12039-013-0382-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12039-013-0382-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- RAOOF JAHAN Electroanalytical Chemistry Research Laboratory, Department of Analytical Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran aut NATIONALLICENCE 700 1- CHEKIN FERESHTEH Department of Chemistry, Islamic Azad University, Ayatollah Amoli Branch, Amol, Iran aut NATIONALLICENCE 700 1- OJANI REZA Electroanalytical Chemistry Research Laboratory, Department of Analytical Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran aut NATIONALLICENCE 700 1- BARARI SAEIDEH Electroanalytical Chemistry Research Laboratory, Department of Analytical Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran aut NATIONALLICENCE 773 0- Journal of Chemical Sciences Springer-Verlag 125/2(2013-03-01), 283-289 0974-3626 125:2<283 2013 125 12039 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer