naa a22 4500 510735134 CHVBK 20180411083007.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s12039-013-0367-0 doi (NATIONALLICENCE)springer-10.1007/s12039-013-0367-0 Synthesis, characterization and biological activity of new cyclization products of 3-(4-substituted benzylidene)-2 H -pyrido[1,2- a ]pyrimidine 2,4-(3 H )-diones [Elektronische Daten] [ABHA BISHNOI, SURUCHI SINGH, ANIL TIWARI, KRISHNA SRIVASTAVA, RAM RAGHUVIR, CHANDRAKANT TRIPATHI] A method is presented for the synthesis of 4-(substituted phenyl)-3-(3-substituted phenyl)4H-spiro[isoxazole-5,3′-pyrido[1,2-a]pyrimidine]-2′,4′-dione (3), 3-(4-substituted phenyl)-3H-isoxazole[3, 4-d]pyrido[1,2-a]pyrimidin-4-(3aH)-one (4) and 3-(4-substituted phenyl) 3,3a-dihydropyrazolo[3,4-d]pyrido[1,2-a]pyrimidin-4-(2H)-one (5) which consists of the conversion of 2H-pyrido[1,2-a]pyrimidine-2,4(3H)-dione (1) to chalcones (2) and their 1,3-dipolar cycloaddition with appropriate aldoximes to give spiro compounds and heterocyclization using amines to yield isoxazolines and pyrazolines. All the compounds were screened for their antimicrobial and antitubercular activity. Graphical Abstract 1,3-Dipolar cycloaddition of pyrido-pyrimidine chalcones with appropriate aldoximes give spiro compounds; heterocyclization using hydroxylamine or hydrazine to yield isoxazolines or pyrazolines, respectively. All the compounds were then screened for their biological (antimicrobial and antitubercular) activity. Indian Academy of Sciences, 2013 Antimicrobial nationallicence antitubercular nationallicence pyrimidine nationallicence spiroisoxazolines nationallicence pyrazoline nationallicence BISHNOI ABHA Department of Chemistry, University of Lucknow, University Road, 226 007, Lucknow, India aut SINGH SURUCHI Department of Chemistry, University of Lucknow, University Road, 226 007, Lucknow, India aut TIWARI ANIL Department of Chemistry, University of Lucknow, University Road, 226 007, Lucknow, India aut SRIVASTAVA KRISHNA Department of Chemistry, Sri Ramswaroop College of Engineering and Management, Faizabad Road, 226 001, Lucknow, India aut RAGHUVIR RAM Division of Pharmacology, Central Drug Research Institute, Chattar Manzil Palace, 226 001, Lucknow, India aut TRIPATHI CHANDRAKANT Division of Pharmacology, Central Drug Research Institute, Chattar Manzil Palace, 226 001, Lucknow, India aut Journal of Chemical Sciences Springer-Verlag 125/2(2013-03-01), 305-312 0974-3626 125:2<305 2013 125 12039 https://doi.org/10.1007/s12039-013-0367-0 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s12039-013-0367-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- BISHNOI ABHA Department of Chemistry, University of Lucknow, University Road, 226 007, Lucknow, India aut NATIONALLICENCE 700 1- SINGH SURUCHI Department of Chemistry, University of Lucknow, University Road, 226 007, Lucknow, India aut NATIONALLICENCE 700 1- TIWARI ANIL Department of Chemistry, University of Lucknow, University Road, 226 007, Lucknow, India aut NATIONALLICENCE 700 1- SRIVASTAVA KRISHNA Department of Chemistry, Sri Ramswaroop College of Engineering and Management, Faizabad Road, 226 001, Lucknow, India aut NATIONALLICENCE 700 1- RAGHUVIR RAM Division of Pharmacology, Central Drug Research Institute, Chattar Manzil Palace, 226 001, Lucknow, India aut NATIONALLICENCE 700 1- TRIPATHI CHANDRAKANT Division of Pharmacology, Central Drug Research Institute, Chattar Manzil Palace, 226 001, Lucknow, India aut NATIONALLICENCE 773 0- Journal of Chemical Sciences Springer-Verlag 125/2(2013-03-01), 305-312 0974-3626 125:2<305 2013 125 12039 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer