naa a22 4500 510735185 CHVBK 20180411083007.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s11904-012-0148-2 doi (NATIONALLICENCE)springer-10.1007/s11904-012-0148-2 Use of Human Mucosal Tissue to Study HIV-1 Pathogenesis and Evaluate HIV-1 Prevention Modalities [Elektronische Daten] [Charlene Dezzutti, Florian Hladik] The use of human mucosal tissue models is an important tool advancing our understanding of the specific mechanisms of sexual HIV transmission. Despite 30years of study, major gaps remain, including how HIV-1 transverses the epithelium and the identity of the early immune targets (gate keepers). Because defining HIV-1 transmission in vivo is difficult, mucosal tissue is being used ex vivo to identify key steps in HIV-1 entry and early dissemination. Elucidating early events of HIV-1 infection will help us develop more potent and specific HIV-1 preventatives such as microbicides and vaccines. Mucosal tissue has been incorporated into testing regimens for antiretroviral drugs and monoclonal antibodies. The use of mucosal tissue recapitulates the epithelium and immune cells that would be exposed in vivo to virus and drug. This review will discuss the use of mucosal tissue to better understand HIV-1 pathogenesis and prevention modalities. Springer Science+Business Media New York, 2012 Mucosal tissue nationallicence Sexual transmission nationallicence Sexual HIV transmission nationallicence HIV-1 infection nationallicence HIV pathogenesis nationallicence Microbicide nationallicence Vaccine nationallicence Explants nationallicence Biopsies nationallicence Dezzutti Charlene Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Magee-Womens Research Institute, 204 Craft Avenue, Rm 503B, 15213, Pittsburgh, PA, USA aut Hladik Florian Department of Obstetrics and Gynecology, University of Washington, Fred Hutchinson Cancer Research Center, 1100 Eastlake Ave. E., E5-147, 98109-1024, Seattle, WA, USA aut Current HIV/AIDS Reports Current Science Inc. 10/1(2013-03-01), 12-20 1548-3568 10:1<12 2013 10 11904 https://doi.org/10.1007/s11904-012-0148-2 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11904-012-0148-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dezzutti Charlene Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Magee-Womens Research Institute, 204 Craft Avenue, Rm 503B, 15213, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Hladik Florian Department of Obstetrics and Gynecology, University of Washington, Fred Hutchinson Cancer Research Center, 1100 Eastlake Ave. E., E5-147, 98109-1024, Seattle, WA, USA aut NATIONALLICENCE 773 0- Current HIV/AIDS Reports Current Science Inc 10/1(2013-03-01), 12-20 1548-3568 10:1<12 2013 10 11904 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer