naa a22 4500 510735207 CHVBK 20180411083007.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s11904-012-0141-9 doi (NATIONALLICENCE)springer-10.1007/s11904-012-0141-9 Methodological Lessons from Clinical Trials and the Future of Microbicide Research [Elektronische Daten] [Ariane van der Straten, Elizabeth Montgomery, Miriam Hartmann, Alexandra Minnis] Interpretation of microbicide trial results has been compromised by challenges to accurate measurement of product adherence and sexual risk behaviors. This article provides an evaluation of the methods used to measure adherence and other sensitive behaviors relevant to assessment of product safety and effectiveness in recently completed trials of vaginal and rectal microbicides. We review the strengths and limitations of existing and novel behavioral measurement strategies and provide recommendations for future trial design with the goal of facilitating the development and identification of safe and effective microbicides for HIV prevention. Springer Science+Business Media New York, 2012 Topical vaginal microbicides nationallicence Rectal microbicides nationallicence Microbicide trial nationallicence Sexual risk behavior nationallicence Gel nationallicence Vaginal ring nationallicence Clinical trials nationallicence Adherence measurement nationallicence Biomarkers nationallicence Pre-exposure Prophylaxis (PrEP) nationallicence HIV prevention nationallicence van der Straten Ariane Women's Global Health Imperative, RTI International, 114 Sansome Street, Suite 500, 94104, San Francisco, CA, USA aut Montgomery Elizabeth Women's Global Health Imperative, RTI International, 114 Sansome Street, Suite 500, 94104, San Francisco, CA, USA aut Hartmann Miriam Women's Global Health Imperative, RTI International, 114 Sansome Street, Suite 500, 94104, San Francisco, CA, USA aut Minnis Alexandra Women's Global Health Imperative, RTI International, 114 Sansome Street, Suite 500, 94104, San Francisco, CA, USA aut Current HIV/AIDS Reports Current Science Inc. 10/1(2013-03-01), 89-102 1548-3568 10:1<89 2013 10 11904 https://doi.org/10.1007/s11904-012-0141-9 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11904-012-0141-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- van der Straten Ariane Women's Global Health Imperative, RTI International, 114 Sansome Street, Suite 500, 94104, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Montgomery Elizabeth Women's Global Health Imperative, RTI International, 114 Sansome Street, Suite 500, 94104, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Hartmann Miriam Women's Global Health Imperative, RTI International, 114 Sansome Street, Suite 500, 94104, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Minnis Alexandra Women's Global Health Imperative, RTI International, 114 Sansome Street, Suite 500, 94104, San Francisco, CA, USA aut NATIONALLICENCE 773 0- Current HIV/AIDS Reports Current Science Inc 10/1(2013-03-01), 89-102 1548-3568 10:1<89 2013 10 11904 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer