naa a22 4500 510735215 CHVBK 20180411083007.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s11904-012-0150-8 doi (NATIONALLICENCE)springer-10.1007/s11904-012-0150-8 Attacking the HIV Reservoir from the Immune and Viral Perspective [Elektronische Daten] [Marta Massanella, Javier Martinez-Picado, Julià Blanco] Upon HIV infection, a subset of latently infected cells carrying transcriptionally inactive integrated proviral DNA (the HIV-1 reservoir) is rapidly established. These cells are the main force behind HIV persistence under highly active antiretroviral therapy (HAART), which only impacts on actively replicating viruses and it is therefore unable to eradicate the infection. However, the case of Timothy Brown, also known as the Berlin patient, demonstrates that eradication is possible, and recent data support the idea that latency may be reverted in vivo, suggesting that it is possible to perturb the HIV-1 reservoir. This may be achieved by implementing both pharmacological and immunological strategies to reactivate HIV-1 from latently infected cells. Nevertheless, reactivation might not be sufficient to eradicate the virus. Reinforcing HIV-1-specific immune responses and blocking potential new events of viral replication will probably help reaching the final goal of eradication or the alternative objective of a functional cure for HIV-1. Springer Science+Business Media New York, 2012 Inflammation nationallicence Latency nationallicence Transcription nationallicence HAART nationallicence Intensification nationallicence Ongoing viral replication nationallicence T cell proliferation nationallicence Massanella Marta University of California San Diego, 9500 Gilman Drive, 92093, La Jolla, CA, USA aut Martinez-Picado Javier AIDS Research Institute IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, IGTP, Universitat Autònoma de Barcelona, 08916, Badalona, Spain aut Blanco Julià AIDS Research Institute IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, IGTP, Universitat Autònoma de Barcelona, 08916, Badalona, Spain aut Current HIV/AIDS Reports Current Science Inc. 10/1(2013-03-01), 33-41 1548-3568 10:1<33 2013 10 11904 https://doi.org/10.1007/s11904-012-0150-8 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11904-012-0150-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Massanella Marta University of California San Diego, 9500 Gilman Drive, 92093, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Martinez-Picado Javier AIDS Research Institute IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, IGTP, Universitat Autònoma de Barcelona, 08916, Badalona, Spain aut NATIONALLICENCE 700 1- Blanco Julià AIDS Research Institute IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, IGTP, Universitat Autònoma de Barcelona, 08916, Badalona, Spain aut NATIONALLICENCE 773 0- Current HIV/AIDS Reports Current Science Inc 10/1(2013-03-01), 33-41 1548-3568 10:1<33 2013 10 11904 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer