naa a22 4500 510735282 CHVBK 20180411083007.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s11904-012-0149-1 doi (NATIONALLICENCE)springer-10.1007/s11904-012-0149-1 Revising the Role of Myeloid cells in HIV Pathogenesis [Elektronische Daten] [Anupriya Aggarwal, Samantha McAllery, Stuart Turville] Lentiviruses are characterized by their ability to infect resting cells, such as CD4 T cells, macrophages and dendritic cells (DC). Cells of myeloid lineage, which herein we include including monocytes, macrophages, and dendritic cells, play a pivotal role in HIV infection by not only promoting transmission and spread but also serving as viral reservoirs. However, the recent discovery of the HIV restriction factor SAMHD1 within myeloid cells has again led us to question the role of this lineage both in HIV transmission and pathogenesis. Herein we will summarize what the potential role of myeloid cells in HIV pathogenesis is and how recent observations have or haven't reshaped this view. Finally we highlight the idea that cells of myeloid lineage are quality rather than quantity HIV substrates. Thus, whilst is may indeed be difficult for a lentivirus like HIV to infect a resting cell like a macrophage and/or Dendritic cell, there are significant benefits in doing so, even at low frequency. Springer Science+Business Media New York, 2012 HIV nationallicence Dendritic cells nationallicence Macrophages nationallicence CD4 T cells nationallicence HIV restriction factors nationallicence SIV VPX nationallicence SAMHD1 nationallicence HIV pathogenesis and treatment nationallicence Myeloid cells nationallicence Aggarwal Anupriya Laboratory of HIV Biology, Immunovirology and Pathogenesis Program, The Kirby Institute, University of New South Wales, 2010, Kensington, NSW, Australia aut McAllery Samantha Laboratory of HIV Biology, Immunovirology and Pathogenesis Program, The Kirby Institute, University of New South Wales, 2010, Kensington, NSW, Australia aut Turville Stuart Laboratory of HIV Biology, Immunovirology and Pathogenesis Program, The Kirby Institute, University of New South Wales, 2010, Kensington, NSW, Australia aut Current HIV/AIDS Reports Current Science Inc. 10/1(2013-03-01), 3-11 1548-3568 10:1<3 2013 10 11904 https://doi.org/10.1007/s11904-012-0149-1 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11904-012-0149-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Aggarwal Anupriya Laboratory of HIV Biology, Immunovirology and Pathogenesis Program, The Kirby Institute, University of New South Wales, 2010, Kensington, NSW, Australia aut NATIONALLICENCE 700 1- McAllery Samantha Laboratory of HIV Biology, Immunovirology and Pathogenesis Program, The Kirby Institute, University of New South Wales, 2010, Kensington, NSW, Australia aut NATIONALLICENCE 700 1- Turville Stuart Laboratory of HIV Biology, Immunovirology and Pathogenesis Program, The Kirby Institute, University of New South Wales, 2010, Kensington, NSW, Australia aut NATIONALLICENCE 773 0- Current HIV/AIDS Reports Current Science Inc 10/1(2013-03-01), 3-11 1548-3568 10:1<3 2013 10 11904 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer