naa a22 4500 510735290 CHVBK 20180411083007.0 cr unu---uuuuu 180411e20130301xx s 000 0 eng 10.1007/s11904-012-0146-4 doi (NATIONALLICENCE)springer-10.1007/s11904-012-0146-4 Immunity and Hepatitis C: A Review [Elektronische Daten] [Rebecca Terilli, Andrea Cox] Hepatitis C virus (HCV) is a major cause of chronic hepatitis and hepatocellular carcinoma worldwide. Due to shared transmission routes, the prevalence of HCV is especially high among individuals infected with HIV. HIV uninfected individuals spontaneously clear HCV approximately 30% of the time, while the rate of control in HIV infected individuals who subsequently acquire HCV is substantially lower. In addition, complications of HCV are more frequent in those with HIV infection, making liver disease the leading cause of non-AIDS-related death in HIV infected individuals. This review summarizes recent advances in understanding the role of the innate and adaptive immune responses to HCV in those with and without HIV. Further defining the interaction between hepatitis C and the host immune system will potentially reveal insights into HCV pathogenesis and the host's ability to prevent persistent infection, as well as direct the development of vaccines. Springer Science+Business Media New York, 2012 Hepatitis C nationallicence HCV nationallicence Viral hepatitis nationallicence Hepatitis nationallicence Immunity nationallicence Innate immune response nationallicence Interferons nationallicence IFN nationallicence Cellular immunity nationallicence Adaptive immune response nationallicence Neutralizing antibodies nationallicence Chronic infection nationallicence Acute infection nationallicence Liver disease nationallicence Spontaneous clearance nationallicence Treatment response nationallicence SVR nationallicence Vaccination nationallicence HIV nationallicence HIV-HCV coinfection nationallicence Coinfection nationallicence T cell response nationallicence B cell response nationallicence Interleukin 18 nationallicence Interleukin 28B nationallicence Virus nationallicence Terilli Rebecca Division of Infectious Diseases, Johns Hopkins University School of Medicine, Rangos Building, Suite 536, 855 N Wolfe St, 21205, Baltimore, MD, USA aut Cox Andrea Division of Infectious Diseases, Johns Hopkins University School of Medicine, Rangos Building, Suite 536, 855 N Wolfe St, 21205, Baltimore, MD, USA aut Current HIV/AIDS Reports Current Science Inc. 10/1(2013-03-01), 51-58 1548-3568 10:1<51 2013 10 11904 https://doi.org/10.1007/s11904-012-0146-4 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11904-012-0146-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Terilli Rebecca Division of Infectious Diseases, Johns Hopkins University School of Medicine, Rangos Building, Suite 536, 855 N Wolfe St, 21205, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Cox Andrea Division of Infectious Diseases, Johns Hopkins University School of Medicine, Rangos Building, Suite 536, 855 N Wolfe St, 21205, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Current HIV/AIDS Reports Current Science Inc 10/1(2013-03-01), 51-58 1548-3568 10:1<51 2013 10 11904 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer