naa a22 4500 510735320 CHVBK 20180411083007.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s11904-013-0171-y doi (NATIONALLICENCE)springer-10.1007/s11904-013-0171-y Spudich Serena Department of Neurology, Yale University, 300 George Street, Room 8300c, 06510, New Haven, CT, USA aut HIV and Neurocognitive Dysfunction [Elektronische Daten] [Serena Spudich] The spectrum of HIV-associated neurocognitive disorder (HAND) has been dramatically altered in the setting of widely available effective antiretroviral therapy (ART). Once culminating in dementia in many individuals infected with HIV, HAND now typically manifests as more subtle, though still morbid, forms of cognitive impairment in persons surviving long-term with treated HIV infection. Despite the substantial improvement in severity of this disorder, the fact that neurologic injury persists despite ART remains a challenge to the community of patients, providers and investigators aiming to optimize quality of life for those living with HIV. Cognitive dysfunction in treated HIV may reflect early irreversible CNS injury accrued before ART is typically initiated, ongoing low-level CNS infection and progressive injury in the setting of ART, or comborbidities including effects of treatment which may confound the beneficial reduction in viral replication and immune activation effected by ART. The Author(s), 2013 HIV/AIDS nationallicence HIV-associated neurocognitive disorder nationallicence Central nervous system nationallicence Antiretroviral therapy nationallicence Acute HIV infection nationallicence Primary HIV infection nationallicence Microglia nationallicence Cerebrospinal fluid nationallicence HIV-associated dementia nationallicence CNS reservoir nationallicence HIV reservoir nationallicence Compartmentalization nationallicence HIV escape nationallicence Viral load nationallicence Neurotoxicity nationallicence Efavirenz nationallicence Monocyte efficacy nationallicence Central nervous system penetration effectiveness nationallicence Blood-brain barrier nationallicence Current HIV/AIDS Reports Springer US; http://www.springer-ny.com 10/3(2013-09-01), 235-243 1548-3568 10:3<235 2013 10 11904 https://doi.org/10.1007/s11904-013-0171-y text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11904-013-0171-y text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Spudich Serena Department of Neurology, Yale University, 300 George Street, Room 8300c, 06510, New Haven, CT, USA aut NATIONALLICENCE 773 0- Current HIV/AIDS Reports Springer US; http://www.springer-ny.com 10/3(2013-09-01), 235-243 1548-3568 10:3<235 2013 10 11904 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer