naa a22 4500 510735339 CHVBK 20180411083007.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s11904-013-0166-8 doi (NATIONALLICENCE)springer-10.1007/s11904-013-0166-8 Non-AIDS-defining Cancers Among HIV-Infected Patients [Elektronische Daten] [James Cutrell, Roger Bedimo] In the highly active antiretroviral therapy (HAART) era, the incidence of non-AIDS-defining cancers (NADC) has increased and contributes to a growing proportion of mortality in the aging HIV-infected population. The underlying pathogenic mechanisms of increased cancer risk are incompletely understood. Potential contributors include oncogenic effects of the HIV virus, immunosuppression, chronic inflammation and immune activation, exposure to HAART, higher rates of oncogenic viral coinfections and traditional cancer risk factors. HIV-infected patients often present with NADC at younger ages with more aggressive or advanced stage disease. However, when standard cancer therapy is given, treatment outcomes appear similar to the non-HIV population. These facts highlight the importance of clinicians' maintaining a high index of suspicion, performing age-appropriate screening, and optimizing cancer therapy. Development of novel strategies for screening, prevention, and treatment of NADC will be required to reverse these epidemiologic trends and improve the survival of HIV-infected patients. Springer Science+Business Media New York (outside the USA), 2013 HIV nationallicence AIDS nationallicence Cancer nationallicence Non-AIDS-defining cancers nationallicence HAART nationallicence Cutrell James Division of Infectious Diseases, University of Texas Southwestern Medical Center, Dallas, Texas, 5323 Harry Hines Blvd., 75390-9113, Dallas, TX, USA aut Bedimo Roger Infectious Diseases Section, VA North Texas Health Care System, Dallas, Texas, 4500 S. Lancaster Road 111-D, 75216, Dallas, TX, USA aut Current HIV/AIDS Reports Springer US; http://www.springer-ny.com 10/3(2013-09-01), 207-216 1548-3568 10:3<207 2013 10 11904 https://doi.org/10.1007/s11904-013-0166-8 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11904-013-0166-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cutrell James Division of Infectious Diseases, University of Texas Southwestern Medical Center, Dallas, Texas, 5323 Harry Hines Blvd., 75390-9113, Dallas, TX, USA aut NATIONALLICENCE 700 1- Bedimo Roger Infectious Diseases Section, VA North Texas Health Care System, Dallas, Texas, 4500 S. Lancaster Road 111-D, 75216, Dallas, TX, USA aut NATIONALLICENCE 773 0- Current HIV/AIDS Reports Springer US; http://www.springer-ny.com 10/3(2013-09-01), 207-216 1548-3568 10:3<207 2013 10 11904 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer