naa a22 4500 510735398 CHVBK 20180411083008.0 cr unu---uuuuu 180411e20130901xx s 000 0 eng 10.1007/s11904-013-0167-7 doi (NATIONALLICENCE)springer-10.1007/s11904-013-0167-7 Walensky Rochelle Department of Medicine, Massachusetts General Hospital, Divisions of Infectious Disease and General Medicine and the Medical Practice Evaluation Center, 50 Staniford Street, 9th Floor, 02114, Boston, MA, USA aut Combination HIV Prevention: The Value and Interpretation of Mathematical Models [Elektronische Daten] [Rochelle Walensky] Mathematical models of HIV prevention interventions often provide critical insights related to programmatic design and economic efficiency. One recent dynamic model by Long et al. highlights that a combination prevention approach - with testing, treatment, circumcision, microbicides and PrEP - may decrease transmissions by over 60% and may be very cost-effective in South Africa. In this analysis, the authors introduce the critical concept of joint effectiveness of preventions programs and demonstrate how some programs operate synergistically (HIV screening coupled with early treatment) while others may create redundancies (microbicides coupled with pre-exposure prophylaxis). Whether combination HIV prevention programs perform with additive, multiplicative or maximal effectiveness will be important to consider in anticipation of their combined transmission impact. Springer Science+Business Media New York, 2013 Combination HIV prevention nationallicence Test and treat nationallicence Mathematical models nationallicence HIV nationallicence Cost-effectiveness nationallicence HIV transmission nationallicence Current HIV/AIDS Reports Springer US; http://www.springer-ny.com 10/3(2013-09-01), 195-198 1548-3568 10:3<195 2013 10 11904 https://doi.org/10.1007/s11904-013-0167-7 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11904-013-0167-7 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Walensky Rochelle Department of Medicine, Massachusetts General Hospital, Divisions of Infectious Disease and General Medicine and the Medical Practice Evaluation Center, 50 Staniford Street, 9th Floor, 02114, Boston, MA, USA aut NATIONALLICENCE 773 0- Current HIV/AIDS Reports Springer US; http://www.springer-ny.com 10/3(2013-09-01), 195-198 1548-3568 10:3<195 2013 10 11904 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer